Second primary cancers in laryngeal cancer patients in Slovenia, 1961–1996

We analysed the incidence of second primary cancers (SPC) in male laryngeal cancer patients in Slovenia and their survival for the period of 1961–1996. Data were taken from the population-based Cancer Registry of Slovenia. The person-years approach was used and the risk for SPC was expressed as a st...

Full description

Saved in:
Bibliographic Details
Published in:European journal of cancer (1990) 2002-06, Vol.38 (9), p.1254-1260
Main Authors: Ećimović, P, Pompe-Kirn, V
Format: Article
Language:English
Subjects:
Biological and medical sciences
Epidemiology
Humans
Incidence
Laryngeal cancer
Laryngeal Neoplasms - mortality
Male
Medical sciences
Middle Aged
Neoplasms, Second Primary - mortality
Otorhinolaryngology. Stomatology
Risk Factors
Second primary cancers
Slovenia
Slovenia - epidemiology
Standardised incidence ratio
Survival
Survival Analysis
Survival Rate
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We analysed the incidence of second primary cancers (SPC) in male laryngeal cancer patients in Slovenia and their survival for the period of 1961–1996. Data were taken from the population-based Cancer Registry of Slovenia. The person-years approach was used and the risk for SPC was expressed as a standardised incidence ratio (SIR). Survival analysis was carried out using the Kaplan–Meier method. Of 2275 male patients, 369 developed SPC (16.2%, total SIR 2.83), most commonly in the head and neck region (SIR 6.07–15.97), lung (SIR 4.15), oesophagus (SIR 4.66), and bladder (SIR 3.0), which points to an important role of common risk factors of smoking and alcohol. SPC were diagnosed in significant excess up to 20 years after the diagnosis of laryngeal cancer. The median survival time from the diagnosis of laryngeal cancer was 3.25 years for patients without a SPC and 6.47 years for patients who developed a SPC. However, the median survival time from the diagnosis of a SPC was only 0.84 years. Patients with laryngeal cancer in Slovenia have a higher risk of developing a SPC than was reported in similar studies in Europe and the USA. This high risk is partly responsible for their relatively poor survival.
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(02)00012-6