Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events

This study sought to determine whether tight glycemic control with a modified glucose-insulin-potassium (GIK) solution in diabetic coronary artery bypass graft (CABG) patients would improve perioperative outcomes. One hundred forty-one diabetic patients undergoing CABG were prospectively randomized...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2004-03, Vol.109 (12), p.1497-1502
Main Authors: LAZAR, Harold L, CHIPKIN, Stuart R, FITZGERALD, Carmel A, YUSHENG BAO, CABRAL, Howard, APSTEIN, Carl S
Format: Article
Language:English
Subjects:
Atrial Fibrillation - prevention & control
Biological and medical sciences
Blood and lymphatic vessels
Blood Glucose - analysis
Cardiology. Vascular system
Cardioplegic Solutions - administration & dosage
Cardioplegic Solutions - therapeutic use
Cardiotonic Agents - administration & dosage
Cardiotonic Agents - therapeutic use
Coronary Artery Bypass
Coronary Stenosis - complications
Coronary Stenosis - surgery
Diabetes Complications
Diabetes Mellitus - blood
Diabetes Mellitus - drug therapy
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Fatty Acids, Nonesterified - blood
Female
Glucose - administration & dosage
Glucose - therapeutic use
Humans
Insulin - administration & dosage
Insulin - therapeutic use
Lactates - blood
Length of Stay - statistics & numerical data
Male
Medical sciences
Middle Aged
Postoperative Complications - prevention & control
Potassium - administration & dosage
Potassium - therapeutic use
Recurrence
Surgical Wound Infection - epidemiology
Treatment Outcome
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Summary:This study sought to determine whether tight glycemic control with a modified glucose-insulin-potassium (GIK) solution in diabetic coronary artery bypass graft (CABG) patients would improve perioperative outcomes. One hundred forty-one diabetic patients undergoing CABG were prospectively randomized to tight glycemic control (serum glucose, 125 to 200 mg/dL) with GIK or standard therapy (serum glucose
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000121747.71054.79