Amyloid myopathy presenting with distal atrophic weakness

Amyloid myopathy is a rare complication of primary amyloidosis usually presenting with proximal muscle weakness. We report a woman with multiple myeloma in whom marked atrophy and weakness of finger flexor muscles were the first manifestations of systemic amyloidosis. Muscle biopsy revealed amyloid...

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Bibliographic Details
Published in:Muscle & nerve 2004-04, Vol.29 (4), p.605-609
Main Authors: Smestad, Cathrine, Monstad, Per, Lindboe, Christian Fredrik, Mygland, Åse
Format: Article
Language:English
Subjects:
Amyloidosis
Amyloidosis - complications
Amyloidosis - pathology
Amyloidosis - therapy
Biological and medical sciences
Blood Vessels - pathology
Diseases of striated muscles. Neuromuscular diseases
Electrodiagnosis
Electromyography
Female
gammopathy
Humans
inclusion-body myopathy
Medical sciences
Metabolic diseases
Middle Aged
Muscle Weakness - etiology
Muscle Weakness - pathology
Muscle Weakness - therapy
Muscle, Skeletal - pathology
Muscular Atrophy - etiology
Muscular Atrophy - pathology
Muscular Atrophy - therapy
Muscular Diseases - complications
Muscular Diseases - pathology
Muscular Diseases - therapy
myeloma
myopathy
Neurology
Other metabolic disorders
Stem Cell Transplantation
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Description
Summary:Amyloid myopathy is a rare complication of primary amyloidosis usually presenting with proximal muscle weakness. We report a woman with multiple myeloma in whom marked atrophy and weakness of finger flexor muscles were the first manifestations of systemic amyloidosis. Muscle biopsy revealed amyloid angiopathy with deposits of lambda light chains in vessel walls. The recognition of amyloid myopathy is important because clinical symptoms may respond to chemotherapy. Muscle Nerve 29:605–609, 2004
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.10528