Hypoadiponectinaemia in South Asian women during pregnancy: evidence of ethnic variation in adiponectin concentration

Aims  People of South Asian descent face an increased risk of Type 2 diabetes mellitus (DM) and coronary artery disease (CAD) compared with other ethnic groups. One candidate factor underlying this risk may be adiponectin, as circulating levels of this adipocyte‐derived protein are reduced in both T...

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Bibliographic Details
Published in:Diabetic medicine 2004-04, Vol.21 (4), p.388-392
Main Authors: Retnakaran, R., Hanley, A. J. G., Raif, N., Connelly, P. W., Sermer, M., Zinman, B.
Format: Article
Language:English
Subjects:
Adiponectin
Adult
Asia, Southeastern - ethnology
Biological and medical sciences
Blood Glucose - analysis
Body Mass Index
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - ethnology
Diabetes, Gestational - blood
Diabetes, Gestational - epidemiology
Diabetes, Gestational - ethnology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
ethnicity
Female
gestational diabetes
Glucose Tolerance Test
Humans
Insulin - blood
Intercellular Signaling Peptides and Proteins
Medical sciences
Ontario - epidemiology
Ontario - ethnology
Pregnancy
Proteins - analysis
South Asian
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Summary:Aims  People of South Asian descent face an increased risk of Type 2 diabetes mellitus (DM) and coronary artery disease (CAD) compared with other ethnic groups. One candidate factor underlying this risk may be adiponectin, as circulating levels of this adipocyte‐derived protein are reduced in both Type 2 DM and CAD. In a recent study, we assessed the relationship between adiponectin and gestational diabetes (GDM), a potential model of early events in the natural history of Type 2 DM. Here, we report the impact of ethnicity on plasma adiponectin concentration in that study. Methods  A cross‐sectional study was performed in 180 women undergoing oral glucose tolerance testing in late second or early third trimester to investigate the relationship between adiponectin and glucose tolerance in pregnancy. Based on self‐reported ethnicity, participants were stratified into three groups: (i) Caucasian (n = 116), (ii) South Asian (n = 31), and (iii) Asian (n = 28). Results  Median adiponectin concentration was much lower in the South Asian group (9.7 µg/ml) than in Caucasians (15.8 µg/ml) or Asians (16.1 µg/ml) (overall P 
ISSN:0742-3071
1464-5491
DOI:10.1111/j.1464-5491.2004.1151.x