Cardiac specific expression of Xenopus Popeye-1

Popeye genes code for putative transmembrane proteins that are predominantly expressed in heart and skeletal muscle. Here we report on the isolation and expression of a previously unknown Xenopus member of this family, Xenopus Popeye-1 ( Xpop-1). Xpop-1 is 60–65% identical to other vertebrate Pop-1...

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Bibliographic Details
Published in:Mechanisms of development 2002-07, Vol.115 (1), p.123-126
Main Authors: Hitz, Marc P., Pandur, Petra, Brand, Thomas, Kühl, Michael
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Cell Adhesion Molecules
Development
DNA, Complementary
Gene Expression
Heart
Heart - embryology
Humans
Molecular Sequence Data
Muscle Proteins - genetics
Myocardium - metabolism
Popeye
Sequence Homology, Amino Acid
Xenopus laevis
Xenopus laevis - embryology
Xenopus laevis - genetics
Xenopus Proteins - genetics
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Summary:Popeye genes code for putative transmembrane proteins that are predominantly expressed in heart and skeletal muscle. Here we report on the isolation and expression of a previously unknown Xenopus member of this family, Xenopus Popeye-1 ( Xpop-1). Xpop-1 is 60–65% identical to other vertebrate Pop-1 genes at the protein level. Whole-mount in situ hybridization studies revealed a highly specific expression of Xpop-1 whose transcripts are restricted to the embryonic heart and become enriched in the forming ventricle. Interestingly, unlike other known vertebrate Popeye genes, Xpop-1 is exclusively expressed in cardiac tissue and absent from skeletal muscle.
ISSN:0925-4773
1872-6356
DOI:10.1016/S0925-4773(02)00085-0