Unrelated peripheral blood and cord blood hematopoietic stem cell transplants for thalassemia major

Allogeneic hematopoietic stem cell transplantation is currently the only curative treatment available for thalassemia major. While sibling donors are usually used, unrelated bone marrow transplants have also recently been found to be successful. In this report of two patients, we show that, besides...

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Bibliographic Details
Published in:American journal of hematology 2004-04, Vol.75 (4), p.209-212
Main Authors: Tan, Patrick Huat‐Chye, Hwang, William Ying Khee, Goh, Yeow Tee, Tan, Poh Lin, Koh, Liang Piu, Tan, Cheng Hoe, Quah, Thuan Chong
Format: Article
Language:English
Subjects:
Anemias. Hemoglobinopathies
beta-Thalassemia - therapy
Biological and medical sciences
Child
Cord Blood Stem Cell Transplantation
Diseases of red blood cells
Hematologic and hematopoietic diseases
Histocompatibility
Humans
Male
Medical sciences
PBSC
Peripheral Blood Stem Cell Transplantation
thalassemia
Transplantation, Homologous
Treatment Outcome
UCBT
unrelated
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Summary:Allogeneic hematopoietic stem cell transplantation is currently the only curative treatment available for thalassemia major. While sibling donors are usually used, unrelated bone marrow transplants have also recently been found to be successful. In this report of two patients, we show that, besides using unrelated bone marrow, peripheral blood stem cell and cord blood transplantations from unrelated donors are viable options. We believe a significant contributory factor in both our cases was the large cell dose used. Am. J. Hematol. 75:209–212, 2004. © 2004 Wiley‐Liss, Inc.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.20015