p53 expression related to the aggressive infiltrative histopathological feature of basal cell carcinoma

p53 expression related to the aggressive infiltrative histopathological feature of basal cell carcinoma Aims: To determine whether the p53 protein expression which is involved in the genesis and progression of various malignant tumours may relate to age, sites or the aggressive histopathological fea...

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Bibliographic Details
Published in:Histopathology 2002-06, Vol.40 (6), p.568-573
Main Authors: Auepemkiate, S, Boonyaphiphat, P, Thongsuksai, P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
basal cell carcinoma
Biological and medical sciences
Carcinoma, Basal Cell - metabolism
Carcinoma, Basal Cell - pathology
Child
Dermatology
Female
histopathological feature
Humans
Immunohistochemistry
Male
Medical sciences
Middle Aged
Multivariate Analysis
Neoplasm Invasiveness
p53 expression
Sex Factors
Tumor Suppressor Protein p53 - biosynthesis
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:p53 expression related to the aggressive infiltrative histopathological feature of basal cell carcinoma Aims: To determine whether the p53 protein expression which is involved in the genesis and progression of various malignant tumours may relate to age, sites or the aggressive histopathological feature of the basal cell carcinoma. Methods and results: One hundred and fifty‐eight basal cell carcinoma specimens from Songklanakarind Hospital, southern Thailand, collected from January 1992 to December 2000, were examined by immunohistochemistry using polyclonal anti‐p53‐CM1 (Novocastra Laboratories, Newcastle, UK; dilution 1:700). p53 protein expression was demonstrated in 48.7% of cases. The multivariate analysis showed that the aggressive infiltrative histopathological type was significantly associated with p53 expression (odds ratio 2.95, 95% confidence interval 1.10–7.90), whereas age, sun‐exposure site, cellular response and fibrosis were not. Conclusions: The p53 expression is found to be related to the aggressive histopathological feature, which may be of predictive value for the behaviour of basal cell carcinoma. However, this result does not support the relation between sun exposure inducing basal cell carcinoma and p53 protein expression.
ISSN:0309-0167
1365-2559
DOI:10.1046/j.1365-2559.2002.01393.x