ASSESSMENT OF PERIPHERAL LYMPHADENOPATHIES: Experience at a Pediatric Hematology-Oncology Department in Turkey

Since a large variety of disorders may lead to lymph node enlargement, determining the cause of peripheral lymphadenopathy (LAP) in children can be difficult. This retrospective study evaluated 200 children who were admitted to an Oncology-Hematology department because of lymphadenopathy and aimed t...

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Bibliographic Details
Published in:Pediatric hematology and oncology 2002, Vol.19 (4), p.211-218
Main Authors: Kumral, Abdullah, Olgun, Nur, Uysal, Kamer Mutafo lu, Çorapcío lu, Funda, Ören, Hale, Saríalio lu, Faik
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Children
Diagnosis, Differential
Etiology
Hematologic and hematopoietic diseases
Hematologic Tests
Hematology
Hospital Departments
Humans
Lymph Nodes - pathology
Lymphatic Diseases - diagnosis
Lymphatic Diseases - etiology
Medical Oncology
Medical sciences
Other diseases. Hematologic involvement in other diseases
Peripheral Lymphadenopathy
Radiography, Thoracic
Retrospective Studies
Turkey
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Summary:Since a large variety of disorders may lead to lymph node enlargement, determining the cause of peripheral lymphadenopathy (LAP) in children can be difficult. This retrospective study evaluated 200 children who were admitted to an Oncology-Hematology department because of lymphadenopathy and aimed to determine the clinical and laboratory findings that were valuable for differential diagnosis. A specific cause for lymphadenopathy was documented in 93 (46.5%) cases. One hundred forty (70%) children were classified as having a benign cause for lymph node enlargements. Fourteen (10%) of these cases underwent an excisional lymph node biopsy, and histopathological examination showed a reactive hyperplasia. Sixty (30%) cases were classified as having a malignant disease-causing lymphadenopathy. In terms of differential diagnosis, some associated systemic symptoms, physical findings, and laboratory investigations showed significant difference between benign and malignant lymphadenopathy groups. The following findings were determined as being important to alert the physician about the probability of a malignant disorder: location of the lymphadenopathy (supraclavicular and posterior auricular), duration of the lymph node enlargement (> 4 weeks), size of the lymph node (> 3cm), abnormal complete blood cell findings, abnormalities in chest X-ray, and abdominal ultrasonography.
ISSN:0888-0018
1521-0669
DOI:10.1080/08880010252899361