Reduced inositol content in lymphocyte-derived cell lines from bipolar patients

Objectives: The study aimed to determine whether low inositol content and uptake previously reported in brain and peripheral tissue of bipolar patients are also reflected in lymphocyte‐derived cell lines from these patients. Methods: Inositol content and uptake were studied in lymphocyte‐derived cel...

Full description

Saved in:
Bibliographic Details
Published in:Bipolar disorders 2002-02, Vol.4 (1), p.67-69
Main Authors: Belmaker, RH, Shapiro, J, Vainer, E, Nemanov, L, Ebstein, RP, Agam, G
Format: Article
Language:English
Subjects:
bipolar disorder
Bipolar Disorder - metabolism
Brain - metabolism
Cells, Cultured
Chromatography, Gas
Female
Frontal Lobe - metabolism
Humans
Inositol - metabolism
inositol content
inositol uptake
lymphocyte-derived cell lines
Lymphocytes - metabolism
Male
Middle Aged
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives: The study aimed to determine whether low inositol content and uptake previously reported in brain and peripheral tissue of bipolar patients are also reflected in lymphocyte‐derived cell lines from these patients. Methods: Inositol content and uptake were studied in lymphocyte‐derived cell lines grown in vitro for at least five generations to eliminate influences of drug treatment. Inositol content was studied gas chromatographically and inositol uptake by following 3H‐inositol incorporation at various concentrations. Results: Inositol levels of cell lines derived from bipolar patients were significantly lower than those of cell lines from controls. Conclusions: Low inositol content in lymphocyte‐derived cell lines from bipolar patients corroborates previous findings in frontal cortex and in lymphoblastoid cell lines and are consistent with the notion that the phosphatidylinositol signaling system is involved in the pathophysiology of this disorder.
ISSN:1398-5647
1399-5618
DOI:10.1034/j.1399-5618.2002.00108.x