Increased Dispersion of Ventricular Repolarization During Head-Up Tilt Test Late After Orthotopic Heart Transplantation in Humans

LEE, T.‐M., et al.: Increased Dispersion of Ventricular Repolarization During Head‐Up Tilt Test Late After Orthotopic Heart Transplantation in Humans. Sympathetic reinnervation after heart transplantation may be regionally heterogeneous. It remains undetermined if such heterogeneous reinnervation wi...

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Bibliographic Details
Published in:Pacing and clinical electrophysiology 2002-05, Vol.25 (5), p.768-775
Main Authors: LEE, TSUNG-MING, CHOU, NAI-KUAN, TSAI, CHANG-HER, KO, WEN-JE, TSAI, PI-RU, WANG, SHOEI-SHEN, CHU, SHU-HSUN
Format: Article
Language:English
Subjects:
Adult
Electrocardiography, Ambulatory
Female
head-up tilt test
Heart - innervation
Heart Rate - physiology
heart transplantation
Heart Transplantation - physiology
Hemodynamics - physiology
Humans
Male
Middle Aged
Prospective Studies
Reproducibility of Results
Risk Factors
Sympathetic Nervous System - physiology
sympathetic reinnervation
Tilt-Table Test
Ventricular Function
ventricular repolarization
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Summary:LEE, T.‐M., et al.: Increased Dispersion of Ventricular Repolarization During Head‐Up Tilt Test Late After Orthotopic Heart Transplantation in Humans. Sympathetic reinnervation after heart transplantation may be regionally heterogeneous. It remains undetermined if such heterogeneous reinnervation will result in increased ventricular repolarization dispersion. To determine the changes of ventricular repolarization after transplantation, a 15‐minute, 80‐degree head‐up tilt test was prospectively performed with isoproterenol provocation in 30 patients who were studied within 5 months after transplantation (early group) and 30 patients who were studied ≥12 months (late group). Holter monitor was initiated to evaluate heart rate variability, which was a surrogate of cardiac reinnervation. JT dispersion was defined as the difference between maximal and minimal JT interval measurements occurring among any of the 12 leads on a standard electrocardiogram. No subject had fewer than nine measurable leads. Compared with patients in the early group, the patients in the late group had higher low frequency activity, indicating partial sympathetic reinnervation. Analysis of the electrocardiogram showed that there were significant differences in the corrected JT dispersion in the late group compared with the early group and controls (74 ± 18 vs 56 ± 15 and 55 ± 14 ms, both P
ISSN:0147-8389
1540-8159
DOI:10.1046/j.1460-9592.2002.t01-1-00768.x