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The effects of maternal mild protein restriction on stroke incidence and blood pressure in stroke-prone spontaneously hypertensive rats (SHRSP)
The effect of maternal protein restriction during pregnancy on the offspring's blood pressure was assessed in stroke-prone spontaneously hypertensive rats (SHRSP) which are genetically predisposed to hypertension and stroke. After the confirmation of pregnancy, the control group was given a 20%...
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| Published in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2004-03, Vol.68 (3), p.488-494 |
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| Main Authors: | , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c661t-5359fe88504d8f4cb29fcacaa64dec54d09cbaf474a498b94e5f48fca0d9ca13 |
| container_end_page | 494 |
| container_issue | 3 |
| container_start_page | 488 |
| container_title | Bioscience, biotechnology, and biochemistry |
| container_volume | 68 |
| creator | Otani, L. (Kinki Univ., Higashiosaka, Osaka (Japan)) Shirasaka, N Yoshizumi, H Murakami, T |
| description | The effect of maternal protein restriction during pregnancy on the offspring's blood pressure was assessed in stroke-prone spontaneously hypertensive rats (SHRSP) which are genetically predisposed to hypertension and stroke. After the confirmation of pregnancy, the control group was given a 20% casein diet, and the low-protein group was fed a 9% casein diet. After the confirmation of delivery, commercial feed was given to both of the groups. No differences were seen between the control and low-protein offspring in regard to body weight, blood pressure elevation, or life span. One percent saline solution was put in the control and low-protein groups after the age of 11 weeks. Blood pressure increased markedly in the low-protein group, on the blood pressure level in the low-protein group on week 2 after salt loading (242±6 mmHg) was significantly higher than that in the control group (223±9 mmHg; p |
| doi_str_mv | 10.1271/bbb.68.488 |
| format | article |
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(Kinki Univ., Higashiosaka, Osaka (Japan)) ; Shirasaka, N ; Yoshizumi, H ; Murakami, T</creator><creatorcontrib>Otani, L. (Kinki Univ., Higashiosaka, Osaka (Japan)) ; Shirasaka, N ; Yoshizumi, H ; Murakami, T</creatorcontrib><description>The effect of maternal protein restriction during pregnancy on the offspring's blood pressure was assessed in stroke-prone spontaneously hypertensive rats (SHRSP) which are genetically predisposed to hypertension and stroke. After the confirmation of pregnancy, the control group was given a 20% casein diet, and the low-protein group was fed a 9% casein diet. After the confirmation of delivery, commercial feed was given to both of the groups. No differences were seen between the control and low-protein offspring in regard to body weight, blood pressure elevation, or life span. One percent saline solution was put in the control and low-protein groups after the age of 11 weeks. Blood pressure increased markedly in the low-protein group, on the blood pressure level in the low-protein group on week 2 after salt loading (242±6 mmHg) was significantly higher than that in the control group (223±9 mmHg; p<0.05). The survival duration was significantly shorter in the low-protein group (113±4 days) than in the control group (135±22 days; p<0.05). These results suggest that maternal protein malnutrition in SHRSP exerted a high salt sensitivity and a malignant influence on stroke incidence on offspring.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.68.488</identifier><identifier>PMID: 15056877</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>Animals ; Biological and medical sciences ; Birth Weight ; BLOOD PRESSURE ; Blood Pressure - physiology ; CARDIOVASCULAR DISEASES ; Diet, Protein-Restricted ; Female ; Fetus - metabolism ; Fundamental and applied biological sciences. Psychology ; HYPERTENSION ; Hypertension - etiology ; Hypertension - physiopathology ; Incidence ; Longevity ; Maternal Nutritional Physiological Phenomena ; MOTHERS ; offspring ; PREGNANCY ; PROGENY ; PROTEIN RESTRICTED DIETS ; protein restriction ; RATS ; Rats, Inbred SHR ; Risk Factors ; salt-loading ; SALTS ; Sodium Chloride - pharmacology ; Stroke - epidemiology ; Stroke - etiology ; stroke-prone spontaneously hypertensive rats ; Weight Gain</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2004-03, Vol.68 (3), p.488-494</ispartof><rights>2004 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2004</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c661t-5359fe88504d8f4cb29fcacaa64dec54d09cbaf474a498b94e5f48fca0d9ca13</citedby><cites>FETCH-LOGICAL-c661t-5359fe88504d8f4cb29fcacaa64dec54d09cbaf474a498b94e5f48fca0d9ca13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15835500$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15056877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otani, L. (Kinki Univ., Higashiosaka, Osaka (Japan))</creatorcontrib><creatorcontrib>Shirasaka, N</creatorcontrib><creatorcontrib>Yoshizumi, H</creatorcontrib><creatorcontrib>Murakami, T</creatorcontrib><title>The effects of maternal mild protein restriction on stroke incidence and blood pressure in stroke-prone spontaneously hypertensive rats (SHRSP)</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>The effect of maternal protein restriction during pregnancy on the offspring's blood pressure was assessed in stroke-prone spontaneously hypertensive rats (SHRSP) which are genetically predisposed to hypertension and stroke. After the confirmation of pregnancy, the control group was given a 20% casein diet, and the low-protein group was fed a 9% casein diet. After the confirmation of delivery, commercial feed was given to both of the groups. No differences were seen between the control and low-protein offspring in regard to body weight, blood pressure elevation, or life span. One percent saline solution was put in the control and low-protein groups after the age of 11 weeks. Blood pressure increased markedly in the low-protein group, on the blood pressure level in the low-protein group on week 2 after salt loading (242±6 mmHg) was significantly higher than that in the control group (223±9 mmHg; p<0.05). The survival duration was significantly shorter in the low-protein group (113±4 days) than in the control group (135±22 days; p<0.05). These results suggest that maternal protein malnutrition in SHRSP exerted a high salt sensitivity and a malignant influence on stroke incidence on offspring.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>BLOOD PRESSURE</subject><subject>Blood Pressure - physiology</subject><subject>CARDIOVASCULAR DISEASES</subject><subject>Diet, Protein-Restricted</subject><subject>Female</subject><subject>Fetus - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HYPERTENSION</subject><subject>Hypertension - etiology</subject><subject>Hypertension - physiopathology</subject><subject>Incidence</subject><subject>Longevity</subject><subject>Maternal Nutritional Physiological Phenomena</subject><subject>MOTHERS</subject><subject>offspring</subject><subject>PREGNANCY</subject><subject>PROGENY</subject><subject>PROTEIN RESTRICTED DIETS</subject><subject>protein restriction</subject><subject>RATS</subject><subject>Rats, Inbred SHR</subject><subject>Risk Factors</subject><subject>salt-loading</subject><subject>SALTS</subject><subject>Sodium Chloride - pharmacology</subject><subject>Stroke - epidemiology</subject><subject>Stroke - etiology</subject><subject>stroke-prone spontaneously hypertensive rats</subject><subject>Weight Gain</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNptkdGLFSEUxiWK9rb10nshRFHB3PSOjvoYS7XFQkt738Vxjq2bo3d1prh_Rf9yXuZGEYEg6u_7zvF8CD2mZE03gr7p-37dyTWT8g5a0ZaJplNM3EUromjXSMbpCXpQyg0h9YLT--iEcsI7KcQK_dxeAwbnwE4FJ4dHM0GOJuDRhwHvcprAR5yhTNnbyaeI66qH9A2wj9YPEC1gEwfch5QOCihlzofHI9ZUkwi47FKcTIQ0l7DH1_sd5Ali8d8BZ1Nrv7w6_3J1-eohuudMKPDouJ-i7ft327Pz5uLzh49nby8a23V0anjLlQMpOWGDdMz2G-WsscZ0bADL2UCU7Y1jghmmZK8YcMdkRcigrKHtKXqx2Nbmbuf6Oz36YiGEpUMtqFBUdZsKPvsHvEnzYUBFU1atiZCqrdTrhbI5lZLB6V32o8l7TYk-ZKRrRrqTumZU4adHy7kfYfiDHkOpwPMjYIo1wWVTB13-4mTLOSGV4wvno0t5ND9SDoOezD6k_FvU_reBJ4vOmaTN11yxT5cbQqonEYq1vwATebgT</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Otani, L. (Kinki Univ., Higashiosaka, Osaka (Japan))</creator><creator>Shirasaka, N</creator><creator>Yoshizumi, H</creator><creator>Murakami, T</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>The effects of maternal mild protein restriction on stroke incidence and blood pressure in stroke-prone spontaneously hypertensive rats (SHRSP)</title><author>Otani, L. (Kinki Univ., Higashiosaka, Osaka (Japan)) ; Shirasaka, N ; Yoshizumi, H ; Murakami, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c661t-5359fe88504d8f4cb29fcacaa64dec54d09cbaf474a498b94e5f48fca0d9ca13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>BLOOD PRESSURE</topic><topic>Blood Pressure - physiology</topic><topic>CARDIOVASCULAR DISEASES</topic><topic>Diet, Protein-Restricted</topic><topic>Female</topic><topic>Fetus - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HYPERTENSION</topic><topic>Hypertension - etiology</topic><topic>Hypertension - physiopathology</topic><topic>Incidence</topic><topic>Longevity</topic><topic>Maternal Nutritional Physiological Phenomena</topic><topic>MOTHERS</topic><topic>offspring</topic><topic>PREGNANCY</topic><topic>PROGENY</topic><topic>PROTEIN RESTRICTED DIETS</topic><topic>protein restriction</topic><topic>RATS</topic><topic>Rats, Inbred SHR</topic><topic>Risk Factors</topic><topic>salt-loading</topic><topic>SALTS</topic><topic>Sodium Chloride - pharmacology</topic><topic>Stroke - epidemiology</topic><topic>Stroke - etiology</topic><topic>stroke-prone spontaneously hypertensive rats</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Otani, L. (Kinki Univ., Higashiosaka, Osaka (Japan))</creatorcontrib><creatorcontrib>Shirasaka, N</creatorcontrib><creatorcontrib>Yoshizumi, H</creatorcontrib><creatorcontrib>Murakami, T</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Otani, L. (Kinki Univ., Higashiosaka, Osaka (Japan))</au><au>Shirasaka, N</au><au>Yoshizumi, H</au><au>Murakami, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of maternal mild protein restriction on stroke incidence and blood pressure in stroke-prone spontaneously hypertensive rats (SHRSP)</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>68</volume><issue>3</issue><spage>488</spage><epage>494</epage><pages>488-494</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>The effect of maternal protein restriction during pregnancy on the offspring's blood pressure was assessed in stroke-prone spontaneously hypertensive rats (SHRSP) which are genetically predisposed to hypertension and stroke. After the confirmation of pregnancy, the control group was given a 20% casein diet, and the low-protein group was fed a 9% casein diet. After the confirmation of delivery, commercial feed was given to both of the groups. No differences were seen between the control and low-protein offspring in regard to body weight, blood pressure elevation, or life span. One percent saline solution was put in the control and low-protein groups after the age of 11 weeks. Blood pressure increased markedly in the low-protein group, on the blood pressure level in the low-protein group on week 2 after salt loading (242±6 mmHg) was significantly higher than that in the control group (223±9 mmHg; p<0.05). The survival duration was significantly shorter in the low-protein group (113±4 days) than in the control group (135±22 days; p<0.05). These results suggest that maternal protein malnutrition in SHRSP exerted a high salt sensitivity and a malignant influence on stroke incidence on offspring.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>15056877</pmid><doi>10.1271/bbb.68.488</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2004-03, Vol.68 (3), p.488-494 |
| issn | 0916-8451 1347-6947 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71791962 |
| source | Oxford Journals Online; EZB Electronic Journals Library |
| subjects | Animals Biological and medical sciences Birth Weight BLOOD PRESSURE Blood Pressure - physiology CARDIOVASCULAR DISEASES Diet, Protein-Restricted Female Fetus - metabolism Fundamental and applied biological sciences. Psychology HYPERTENSION Hypertension - etiology Hypertension - physiopathology Incidence Longevity Maternal Nutritional Physiological Phenomena MOTHERS offspring PREGNANCY PROGENY PROTEIN RESTRICTED DIETS protein restriction RATS Rats, Inbred SHR Risk Factors salt-loading SALTS Sodium Chloride - pharmacology Stroke - epidemiology Stroke - etiology stroke-prone spontaneously hypertensive rats Weight Gain |
| title | The effects of maternal mild protein restriction on stroke incidence and blood pressure in stroke-prone spontaneously hypertensive rats (SHRSP) |
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