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Urinary albumin excretion is related to cardiovascular risk indicators, not to flow-mediated vasodilation, in apparently healthy subjects
Based on studies in diabetic and hypertensive populations it has been postulated that early endothelial dysfunction is the mechanism responsible for the increased cardiovascular risk in microalbuminuric subjects. We evaluated the relation between microalbuminuria and endothelial dysfunction, assesse...
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| Published in: | Atherosclerosis 2002-07, Vol.163 (1), p.121-126 |
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| creator | Diercks, Gilles F.H Stroes, Erik S.G Boven, Ad J.van Roon, Arie M.van Hillege, Hans L Jong, P.E.de Smit, Andries J Gans, Rijk O.B Crijns, Harry J.G.M Rabelink, Ton J Gilst, Wiek H.van |
| description | Based on studies in diabetic and hypertensive populations it has been postulated that early endothelial dysfunction is the mechanism responsible for the increased cardiovascular risk in microalbuminuric subjects. We evaluated the relation between microalbuminuria and endothelial dysfunction, assessed as flow-mediated dilation of the brachial artery, in an apparently healthy population. Within the framework of the PREVEND Intervention Trial non-hypertensive and non-hypercholesterolemic subjects were recruited on the basis of reproducible microalbuminuria. Using high-resolution ultrasound, flow-mediated dilation and nitroglycerin-mediated dilation of the brachial artery was assessed to measure endothelium-dependent and endothelium-independent responses, respectively. For the current study subjects with diabetes mellitus, clinical atherosclerosis, and macroalbuminuria were excluded from the analyses. We studied 421 men and 233 women (mean age (SD) 50 (12)). Increasing levels of urinary albumin excretion were accompanied by a significant increase in age, percentage men, systolic and diastolic blood pressure, body mass index, and serum triglycerides, whereas there was no decrease of flow-mediated vasodilation or nitroglycerin-mediated vasodilation. Adjusted for age and sex, urinary albumin excretion was significantly related to systolic (
r=0.19,
P |
| doi_str_mv | 10.1016/S0021-9150(01)00748-1 |
| format | article |
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r=0.19,
P<0.001) and diastolic (
r=0.16,
P<0.001) blood pressure, body mass index (
r=0.18,
P<0.001), and triglycerides (
r=0.13,
P=0.001), but not to flow-mediated vasodilation (
r=−0.01,
P=0.8). In contrast to blood pressure, body mass index, and triglycerides, there was no relation between urinary albumin excretion and flow-mediated vasodilation in apparently healthy subjects. These data suggest that the presence of atherogenic risk factors precedes the development of endothelial dysfunction in microalbuminuric, but otherwise healthy subjects.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/S0021-9150(01)00748-1</identifier><identifier>PMID: 12048129</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Adult ; Age Factors ; Albuminuria - diagnosis ; Biological and medical sciences ; Blood Flow Velocity ; Brachial Artery - pathology ; Brachial Artery - physiopathology ; Cardiology. Vascular system ; Cardiovascular Diseases - diagnostic imaging ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Coronary heart disease ; Endothelium ; Endothelium, Vascular - diagnostic imaging ; Female ; Heart ; Humans ; Male ; Medical sciences ; Microalbuminuria ; Middle Aged ; Probability ; Prospective Studies ; Reference Values ; Risk Assessment ; Risk Factors ; Sensitivity and Specificity ; Sex Factors ; Ultrasonography ; Urinalysis ; Vasodilation - physiology</subject><ispartof>Atherosclerosis, 2002-07, Vol.163 (1), p.121-126</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-e623685cc1173dd495941acf0bd1c0d4d4f2db35b95ee8097716df9ced2c42cf3</citedby><cites>FETCH-LOGICAL-c391t-e623685cc1173dd495941acf0bd1c0d4d4f2db35b95ee8097716df9ced2c42cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13687971$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12048129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diercks, Gilles F.H</creatorcontrib><creatorcontrib>Stroes, Erik S.G</creatorcontrib><creatorcontrib>Boven, Ad J.van</creatorcontrib><creatorcontrib>Roon, Arie M.van</creatorcontrib><creatorcontrib>Hillege, Hans L</creatorcontrib><creatorcontrib>Jong, P.E.de</creatorcontrib><creatorcontrib>Smit, Andries J</creatorcontrib><creatorcontrib>Gans, Rijk O.B</creatorcontrib><creatorcontrib>Crijns, Harry J.G.M</creatorcontrib><creatorcontrib>Rabelink, Ton J</creatorcontrib><creatorcontrib>Gilst, Wiek H.van</creatorcontrib><title>Urinary albumin excretion is related to cardiovascular risk indicators, not to flow-mediated vasodilation, in apparently healthy subjects</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Based on studies in diabetic and hypertensive populations it has been postulated that early endothelial dysfunction is the mechanism responsible for the increased cardiovascular risk in microalbuminuric subjects. We evaluated the relation between microalbuminuria and endothelial dysfunction, assessed as flow-mediated dilation of the brachial artery, in an apparently healthy population. Within the framework of the PREVEND Intervention Trial non-hypertensive and non-hypercholesterolemic subjects were recruited on the basis of reproducible microalbuminuria. Using high-resolution ultrasound, flow-mediated dilation and nitroglycerin-mediated dilation of the brachial artery was assessed to measure endothelium-dependent and endothelium-independent responses, respectively. For the current study subjects with diabetes mellitus, clinical atherosclerosis, and macroalbuminuria were excluded from the analyses. We studied 421 men and 233 women (mean age (SD) 50 (12)). Increasing levels of urinary albumin excretion were accompanied by a significant increase in age, percentage men, systolic and diastolic blood pressure, body mass index, and serum triglycerides, whereas there was no decrease of flow-mediated vasodilation or nitroglycerin-mediated vasodilation. Adjusted for age and sex, urinary albumin excretion was significantly related to systolic (
r=0.19,
P<0.001) and diastolic (
r=0.16,
P<0.001) blood pressure, body mass index (
r=0.18,
P<0.001), and triglycerides (
r=0.13,
P=0.001), but not to flow-mediated vasodilation (
r=−0.01,
P=0.8). In contrast to blood pressure, body mass index, and triglycerides, there was no relation between urinary albumin excretion and flow-mediated vasodilation in apparently healthy subjects. These data suggest that the presence of atherogenic risk factors precedes the development of endothelial dysfunction in microalbuminuric, but otherwise healthy subjects.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Albuminuria - diagnosis</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Brachial Artery - pathology</subject><subject>Brachial Artery - physiopathology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - diagnostic imaging</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Coronary heart disease</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - diagnostic imaging</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microalbuminuria</subject><subject>Middle Aged</subject><subject>Probability</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Sex Factors</subject><subject>Ultrasonography</subject><subject>Urinalysis</subject><subject>Vasodilation - physiology</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAURi0EotPCI4C8AYHUgG_ijONVharyI1ViAV1bjn2junjswXYK8wi8Nc7MiC5ZeXPud33PR8gLYO-Awfr9N8ZaaCT07A2Dt4wJPjTwiKxgELIBPvDHZPUPOSGnOd8xxriA4Sk5gZbxAVq5In9ukgs67aj247xxgeJvk7C4GKjLNKHXBS0tkRqdrIv3OpvZ60STyz-oC9YZXWLK5zTEsmCTj7-aDVq3n6t4tK5m1LzzilO93eqEofgdvUXty-2O5nm8Q1PyM_Jk0j7j8-N7Rm4-Xn2__Nxcf_305fLDdWM6CaXBdduth94YANFZy2UvOWgzsdGCYZZbPrV27PpR9ogDk0LA2k7SoG0Nb83UnZHXh9xtij9nzEVtXDbovQ4Y56wECNkCQAX7A2hSzDnhpLbJbaorBUwtHah9B2oRrBiofQdqmXt5XDCP1cTD1FF6BV4dgWpT-ynpYFx-4Op9Qool6OLAYdVx7zCpbByGeopL1Ziy0f3nK38B2aumyg</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Diercks, Gilles F.H</creator><creator>Stroes, Erik S.G</creator><creator>Boven, Ad J.van</creator><creator>Roon, Arie M.van</creator><creator>Hillege, Hans L</creator><creator>Jong, P.E.de</creator><creator>Smit, Andries J</creator><creator>Gans, Rijk O.B</creator><creator>Crijns, Harry J.G.M</creator><creator>Rabelink, Ton J</creator><creator>Gilst, Wiek H.van</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020701</creationdate><title>Urinary albumin excretion is related to cardiovascular risk indicators, not to flow-mediated vasodilation, in apparently healthy subjects</title><author>Diercks, Gilles F.H ; Stroes, Erik S.G ; Boven, Ad J.van ; Roon, Arie M.van ; Hillege, Hans L ; Jong, P.E.de ; Smit, Andries J ; Gans, Rijk O.B ; Crijns, Harry J.G.M ; Rabelink, Ton J ; Gilst, Wiek H.van</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-e623685cc1173dd495941acf0bd1c0d4d4f2db35b95ee8097716df9ced2c42cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Albuminuria - diagnosis</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Brachial Artery - pathology</topic><topic>Brachial Artery - physiopathology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - diagnostic imaging</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Coronary heart disease</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - diagnostic imaging</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microalbuminuria</topic><topic>Middle Aged</topic><topic>Probability</topic><topic>Prospective Studies</topic><topic>Reference Values</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Sex Factors</topic><topic>Ultrasonography</topic><topic>Urinalysis</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diercks, Gilles F.H</creatorcontrib><creatorcontrib>Stroes, Erik S.G</creatorcontrib><creatorcontrib>Boven, Ad J.van</creatorcontrib><creatorcontrib>Roon, Arie M.van</creatorcontrib><creatorcontrib>Hillege, Hans L</creatorcontrib><creatorcontrib>Jong, P.E.de</creatorcontrib><creatorcontrib>Smit, Andries J</creatorcontrib><creatorcontrib>Gans, Rijk O.B</creatorcontrib><creatorcontrib>Crijns, Harry J.G.M</creatorcontrib><creatorcontrib>Rabelink, Ton J</creatorcontrib><creatorcontrib>Gilst, Wiek H.van</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diercks, Gilles F.H</au><au>Stroes, Erik S.G</au><au>Boven, Ad J.van</au><au>Roon, Arie M.van</au><au>Hillege, Hans L</au><au>Jong, P.E.de</au><au>Smit, Andries J</au><au>Gans, Rijk O.B</au><au>Crijns, Harry J.G.M</au><au>Rabelink, Ton J</au><au>Gilst, Wiek H.van</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary albumin excretion is related to cardiovascular risk indicators, not to flow-mediated vasodilation, in apparently healthy subjects</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>163</volume><issue>1</issue><spage>121</spage><epage>126</epage><pages>121-126</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Based on studies in diabetic and hypertensive populations it has been postulated that early endothelial dysfunction is the mechanism responsible for the increased cardiovascular risk in microalbuminuric subjects. We evaluated the relation between microalbuminuria and endothelial dysfunction, assessed as flow-mediated dilation of the brachial artery, in an apparently healthy population. Within the framework of the PREVEND Intervention Trial non-hypertensive and non-hypercholesterolemic subjects were recruited on the basis of reproducible microalbuminuria. Using high-resolution ultrasound, flow-mediated dilation and nitroglycerin-mediated dilation of the brachial artery was assessed to measure endothelium-dependent and endothelium-independent responses, respectively. For the current study subjects with diabetes mellitus, clinical atherosclerosis, and macroalbuminuria were excluded from the analyses. We studied 421 men and 233 women (mean age (SD) 50 (12)). Increasing levels of urinary albumin excretion were accompanied by a significant increase in age, percentage men, systolic and diastolic blood pressure, body mass index, and serum triglycerides, whereas there was no decrease of flow-mediated vasodilation or nitroglycerin-mediated vasodilation. Adjusted for age and sex, urinary albumin excretion was significantly related to systolic (
r=0.19,
P<0.001) and diastolic (
r=0.16,
P<0.001) blood pressure, body mass index (
r=0.18,
P<0.001), and triglycerides (
r=0.13,
P=0.001), but not to flow-mediated vasodilation (
r=−0.01,
P=0.8). In contrast to blood pressure, body mass index, and triglycerides, there was no relation between urinary albumin excretion and flow-mediated vasodilation in apparently healthy subjects. These data suggest that the presence of atherogenic risk factors precedes the development of endothelial dysfunction in microalbuminuric, but otherwise healthy subjects.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>12048129</pmid><doi>10.1016/S0021-9150(01)00748-1</doi><tpages>6</tpages></addata></record> |
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| ispartof | Atherosclerosis, 2002-07, Vol.163 (1), p.121-126 |
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| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Adult Age Factors Albuminuria - diagnosis Biological and medical sciences Blood Flow Velocity Brachial Artery - pathology Brachial Artery - physiopathology Cardiology. Vascular system Cardiovascular Diseases - diagnostic imaging Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Coronary heart disease Endothelium Endothelium, Vascular - diagnostic imaging Female Heart Humans Male Medical sciences Microalbuminuria Middle Aged Probability Prospective Studies Reference Values Risk Assessment Risk Factors Sensitivity and Specificity Sex Factors Ultrasonography Urinalysis Vasodilation - physiology |
| title | Urinary albumin excretion is related to cardiovascular risk indicators, not to flow-mediated vasodilation, in apparently healthy subjects |
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