A cluster of candidate odorant receptors from the malaria vector mosquito, Anopheles gambiae

Olfaction is critical to the host preference selection behavior of many disease-transmitting insects, including the mosquito Anopheles gambiae sensu stricto (hereafter A. gambiae), one of the major vectors for human malaria. In order to more fully understand the molecular biology of olfaction in thi...

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Bibliographic Details
Published in:Chemical senses 2002-06, Vol.27 (5), p.453-459
Main Authors: FOX, A. N, PITTS, R. J, ZWIEBEL, L. J
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Anopheles - genetics
Anopheles - growth & development
Anopheles - physiology
Anopheles gambiae
Biochemistry. Physiology. Immunology
Biological and medical sciences
Chromosomes, Artificial, Bacterial - genetics
Culicidae
Drosophila melanogaster - genetics
Female
Freshwater
Fundamental and applied biological sciences. Psychology
Genes, Insect - genetics
Insect Vectors - genetics
Insect Vectors - physiology
Insecta
Invertebrates
Malaria - transmission
Male
Molecular Sequence Data
Phylogeny
Physiology. Development
Receptors, Odorant - biosynthesis
Receptors, Odorant - genetics
Receptors, Odorant - physiology
Sequence Homology, Amino Acid
Species Specificity
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Summary:Olfaction is critical to the host preference selection behavior of many disease-transmitting insects, including the mosquito Anopheles gambiae sensu stricto (hereafter A. gambiae), one of the major vectors for human malaria. In order to more fully understand the molecular biology of olfaction in this insect, we have previously identified several members member of a family of candidate odorant receptor proteins from A. gambiae (AgORs). Here we report the cloning and characterization of an additional AgOR gene, denoted as AgOr5, which shows significant similarity to putative odorant receptors in A. gambiae and Drosophila melanogaster and which is selectively expressed in olfactory organs. AgOr5 is tightly clustered within the A. gambiae genome to two other highly homologous candidate odorant receptors, suggesting that these genes are derived from a common ancestor. Analysis of the developmental expression within members of this AgOR gene cluster reveals considerable variation between these AgORs as compared to candidate odorant receptors from D. melanogaster.
ISSN:0379-864X
1464-3553
1464-3553
DOI:10.1093/chemse/27.5.453