Gold derivatives for the treatment of cancer

The cytotoxicity and anti-tumour activity screening trials for both gold(I) and gold(III) are summarised. Gold(I) thiolates employed clinically in the treatment of rheumatoid arthritis display some potency against various tumours but a greater potential is found in their analogues. In particular, an...

Full description

Saved in:
Bibliographic Details
Published in:Critical reviews in oncology/hematology 2002-06, Vol.42 (3), p.225-248
Main Author: Tiekink, Edward R.T.
Format: Article
Language:English
Subjects:
Animals
Cancer
Drug Evaluation, Preclinical
Gold Compounds - chemistry
Gold Compounds - pharmacology
Gold Compounds - therapeutic use
Gold(I)
Gold(III)
Humans
Molecular Structure
Neoplasms - drug therapy
Phosphines
Rheumatoid arthritis
Structure-Activity Relationship
Thiolates
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The cytotoxicity and anti-tumour activity screening trials for both gold(I) and gold(III) are summarised. Gold(I) thiolates employed clinically in the treatment of rheumatoid arthritis display some potency against various tumours but a greater potential is found in their analogues. In particular, analogues featuring a linear PAuS arrangement in which the thiolate ligand is derived from a biologically active thiol display high potency. Further, targeting mitochondria with tetrahedrally coordinated gold(I) phosphine compounds with enhanced hydrophilicity is a research direction with exciting potential. Recent research has shown that gold(III) compounds featuring square-planar geometries, as found in cisplatin, may target DNA and may provide new anti-tumour agents.
ISSN:1040-8428
1879-0461
DOI:10.1016/S1040-8428(01)00216-5