Prognostic importance of leukoaraiosis in patients with symptomatic internal carotid artery stenosis

Leukoaraiosis (LA) is a frequent finding on brain CT scans. This study examined patients with LA and symptomatic internal carotid artery disease. Patients in the North American Symptomatic Carotid Endarterectomy Trial were evaluated for the extent of LA. Long-term prognosis and perioperative risk as...

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Bibliographic Details
Published in:Stroke (1970) 2002-06, Vol.33 (6), p.1651-1655
Main Authors: STREIFLER, Jonathan Y, ELIASZIW, Michael, BENAVENTE, Oscar R, ALAMOWITCH, Sonia, FOX, Allan J, HACHINSKI, Vladimir C, BARNETT, Henry J. M
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Brain - blood supply
Brain - diagnostic imaging
Carotid Artery Diseases - diagnosis
Carotid Artery Diseases - epidemiology
Carotid Artery Diseases - surgery
Cerebrovascular Disorders - diagnosis
Cerebrovascular Disorders - diagnostic imaging
Cerebrovascular Disorders - epidemiology
Comorbidity
Endarterectomy, Carotid - adverse effects
Female
Follow-Up Studies
Humans
Incidence
Ischemic Attack, Transient - diagnosis
Ischemic Attack, Transient - epidemiology
Ischemic Attack, Transient - prevention & control
Male
Medical sciences
Middle Aged
Multicenter Studies as Topic - statistics & numerical data
Neurology
North America - epidemiology
Odds Ratio
Prognosis
Randomized Controlled Trials as Topic - statistics & numerical data
Risk
Risk Assessment
Stroke - diagnosis
Stroke - epidemiology
Stroke - prevention & control
Tomography, X-Ray Computed
Vascular diseases and vascular malformations of the nervous system
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Summary:Leukoaraiosis (LA) is a frequent finding on brain CT scans. This study examined patients with LA and symptomatic internal carotid artery disease. Patients in the North American Symptomatic Carotid Endarterectomy Trial were evaluated for the extent of LA. Long-term prognosis and perioperative risk associated with carotid endarterectomy were assessed. Among 2618 patients, 493 had LA: 354 restricted and 139 widespread. Patients with LA were older, had a history of hypertension, had more hemispheric ischemic events (particularly stroke), and had small, deep brain infarcts. The 3-year risks of stroke for medically treated patients were 20.2% (no LA), 27.3% (restricted LA), and 37.2% (widespread LA) (P=0.01). For surgically treated patients, the risks were 14.2%, 25.4%, and 33.6%, respectively (P
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000018010.38749.08