Determining drug spatial distribution within controlled delivery tablets using MFX imaging

In this study, the potential of micro-focus X-ray (MFX) imaging as a tool in the design and quality control of drug delivery systems has been demonstrated. MFX imaging has been used to map the spatial distribution of a drug down to length-scales of ∼10–100 μm and has shown that the spatial distribut...

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Bibliographic Details
Published in:Journal of controlled release 2004-04, Vol.96 (1), p.97-100
Main Authors: Rigby, Sean P., Van der Walle, Christopher F., Raistrick, James H.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemistry, Pharmaceutical - methods
Delayed-Action Preparations - chemistry
Drug spatial distribution
General pharmacology
Medical sciences
MFX imaging
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Radiography - methods
Tablets
X-Rays
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Summary:In this study, the potential of micro-focus X-ray (MFX) imaging as a tool in the design and quality control of drug delivery systems has been demonstrated. MFX imaging has been used to map the spatial distribution of a drug down to length-scales of ∼10–100 μm and has shown that the spatial distribution of the drug amiodarone within a hydroxypropylmethylcellulose (HPMC) controlled release tablet (diameter 10 mm) is not homogeneous. MFX imaging allows an assessment to be made of the degree of mixing of the original powders. Despite vigorous mixing during the manufacture of the tablets, the drug particles, originally of size 180–420 μm, were found to be concentrated within isolated but spatially extended patches of sizes up to 1 mm that were scattered across the tablet.
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2004.01.007