Increased leptin concentrations and lack of gender difference in Type 2 diabetic patients with nephropathy

Leptin plays an important role in the regulation of body weight and energy balance. Women have higher circulating leptin level than men. In this study, we examined serum leptin concentrations in Type 2 diabetic men and women with or without nephropathy. Fasting plasma glucose (FPG), lipid profile, a...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2004-05, Vol.64 (2), p.93-98
Main Authors: Chan, W.B., Ma, R.C.W., Chan, N.N., Ng, M.C.Y., Lee, Z.S.K., Lai, C.W.K., Tong, P.C.Y., So, W.Y., Chan, J.C.N.
Format: Article
Language:English
Subjects:
Adult
Albuminuria - etiology
Analysis of Variance
Body Mass Index
Case-Control Studies
Chinese
Creatinine - urine
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - pathology
Diabetes Mellitus, Type 2 - urine
Diabetic Nephropathies - etiology
Diabetic nephropathy
Female
Gender
Humans
Leptin
Leptin - blood
Male
Middle Aged
Osmolar Concentration
Sex Characteristics
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Summary:Leptin plays an important role in the regulation of body weight and energy balance. Women have higher circulating leptin level than men. In this study, we examined serum leptin concentrations in Type 2 diabetic men and women with or without nephropathy. Fasting plasma glucose (FPG), lipid profile, and serum leptin concentrations were measured in 34 Type 2 diabetic patients with nephropathy (DMN), 12 normoalbuminuric Type 2 diabetic subjects (DM) and 34 non-diabetic control subjects, all matched for age and body mass index (BMI). Result: Patients with diabetic nephropathy had lower high-density lipoprotein cholesterol and higher triglyceride, FPG, urinary albumin/creatinine ratio (ACR) and serum creatinine than the other two groups. There was a significant trend in serum leptin concentrations ( P
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2003.10.023