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Increased leptin concentrations and lack of gender difference in Type 2 diabetic patients with nephropathy
Leptin plays an important role in the regulation of body weight and energy balance. Women have higher circulating leptin level than men. In this study, we examined serum leptin concentrations in Type 2 diabetic men and women with or without nephropathy. Fasting plasma glucose (FPG), lipid profile, a...
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| Published in: | Diabetes research and clinical practice 2004-05, Vol.64 (2), p.93-98 |
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| container_end_page | 98 |
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| container_title | Diabetes research and clinical practice |
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| creator | Chan, W.B. Ma, R.C.W. Chan, N.N. Ng, M.C.Y. Lee, Z.S.K. Lai, C.W.K. Tong, P.C.Y. So, W.Y. Chan, J.C.N. |
| description | Leptin plays an important role in the regulation of body weight and energy balance. Women have higher circulating leptin level than men. In this study, we examined serum leptin concentrations in Type 2 diabetic men and women with or without nephropathy. Fasting plasma glucose (FPG), lipid profile, and serum leptin concentrations were measured in 34 Type 2 diabetic patients with nephropathy (DMN), 12 normoalbuminuric Type 2 diabetic subjects (DM) and 34 non-diabetic control subjects, all matched for age and body mass index (BMI).
Result: Patients with diabetic nephropathy had lower high-density lipoprotein cholesterol and higher triglyceride, FPG, urinary albumin/creatinine ratio (ACR) and serum creatinine than the other two groups. There was a significant trend in serum leptin concentrations (
P |
| doi_str_mv | 10.1016/j.diabres.2003.10.023 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71797080</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168822703002948</els_id><sourcerecordid>71797080</sourcerecordid><originalsourceid>FETCH-LOGICAL-c361t-6953c30ba8843716453154af4ccd74153842c6ad04e8ee2fc1924e58660cd1733</originalsourceid><addsrcrecordid>eNqFkE1PAyEQhonR2Fr9CRpO3lr5WpaejGn8aNLESz0TCrOW2rIrbDX997J2E4-emAzPywwPQteUTCih8m4zcd6sIqQJI4Tn3oQwfoKGVJVsrBgrT9Ewc-q3HqCLlDaEEMlFcY4GtMiVJHSINvNgI5gEDm-haX3Atg4WQhtN6-uQsAn5xtgPXFf4HYKDiJ2vKoiQMZz55aEBzHC3DbTe4iYHcz7hb9-ucYBmHevcWx8u0Vlltgmu-nOE3p4el7OX8eL1eT57WIwtl7Qdy2nBLScro5TgJZWi4LQQphLWulLQgivBrDSOCFAArLJ0ygQUSkpiHS05H6Hb47tNrD_3kFq988nCdmsC1PukS1pOS6JIBosjaGOdUoRKN9HvTDxoSnQnWW90L1l3krt2lpxzN_2A_WoH7i_VW83A_RGA_M0vD1En6ztfzkewrXa1_2fED590kIM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71797080</pqid></control><display><type>article</type><title>Increased leptin concentrations and lack of gender difference in Type 2 diabetic patients with nephropathy</title><source>ScienceDirect Journals</source><creator>Chan, W.B. ; Ma, R.C.W. ; Chan, N.N. ; Ng, M.C.Y. ; Lee, Z.S.K. ; Lai, C.W.K. ; Tong, P.C.Y. ; So, W.Y. ; Chan, J.C.N.</creator><creatorcontrib>Chan, W.B. ; Ma, R.C.W. ; Chan, N.N. ; Ng, M.C.Y. ; Lee, Z.S.K. ; Lai, C.W.K. ; Tong, P.C.Y. ; So, W.Y. ; Chan, J.C.N.</creatorcontrib><description>Leptin plays an important role in the regulation of body weight and energy balance. Women have higher circulating leptin level than men. In this study, we examined serum leptin concentrations in Type 2 diabetic men and women with or without nephropathy. Fasting plasma glucose (FPG), lipid profile, and serum leptin concentrations were measured in 34 Type 2 diabetic patients with nephropathy (DMN), 12 normoalbuminuric Type 2 diabetic subjects (DM) and 34 non-diabetic control subjects, all matched for age and body mass index (BMI).
Result: Patients with diabetic nephropathy had lower high-density lipoprotein cholesterol and higher triglyceride, FPG, urinary albumin/creatinine ratio (ACR) and serum creatinine than the other two groups. There was a significant trend in serum leptin concentrations (
P<0.001, analysis of variance ANOVA) across the three groups with the main difference being detected between DMN and control subjects (DMN: 17.5±16.8
ng/ml, DM: 14.6±10.5
ng/ml and control: 9.1±7.1
ng/ml). Women had higher serum leptin concentration than men in the control group (12.5±7.3
ng/ml versus 4.2±2.0
ng/ml,
P=0.001) and in the DM group (18.9±11
ng/ml versus 8.6±5.9
ng/ml,
P=0.07) whereas this gender difference was not observed in the DMN group (18.6±17.0
ng/ml versus 16.8±17.0
ng/ml,
P=0.754). On multivariate analysis, ACR (
β=0.411,
P<0.001) and BMI (
β=0.240,
P=0.002) were independently associated with serum leptin concentrations (
R
2=0.194,
F=22.1,
P<0.001) in the whole group. In the DMN group, ACR (
β=0.370,
P=0.016) was the only independent determinant of serum leptin concentrations (
R
2=0.159,
F=11.4,
P=0.016). Serum leptin concentrations were higher in Type 2 diabetic patients with nephropathy than normoalbuminuric diabetic patients and controls. Diabetic men with nephropathy had proportionally higher serum leptin such that the gender difference in leptin observed in non-nephropathic individuals was abolished.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2003.10.023</identifier><identifier>PMID: 15063601</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Albuminuria - etiology ; Analysis of Variance ; Body Mass Index ; Case-Control Studies ; Chinese ; Creatinine - urine ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - pathology ; Diabetes Mellitus, Type 2 - urine ; Diabetic Nephropathies - etiology ; Diabetic nephropathy ; Female ; Gender ; Humans ; Leptin ; Leptin - blood ; Male ; Middle Aged ; Osmolar Concentration ; Sex Characteristics</subject><ispartof>Diabetes research and clinical practice, 2004-05, Vol.64 (2), p.93-98</ispartof><rights>2003 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-6953c30ba8843716453154af4ccd74153842c6ad04e8ee2fc1924e58660cd1733</citedby><cites>FETCH-LOGICAL-c361t-6953c30ba8843716453154af4ccd74153842c6ad04e8ee2fc1924e58660cd1733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15063601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, W.B.</creatorcontrib><creatorcontrib>Ma, R.C.W.</creatorcontrib><creatorcontrib>Chan, N.N.</creatorcontrib><creatorcontrib>Ng, M.C.Y.</creatorcontrib><creatorcontrib>Lee, Z.S.K.</creatorcontrib><creatorcontrib>Lai, C.W.K.</creatorcontrib><creatorcontrib>Tong, P.C.Y.</creatorcontrib><creatorcontrib>So, W.Y.</creatorcontrib><creatorcontrib>Chan, J.C.N.</creatorcontrib><title>Increased leptin concentrations and lack of gender difference in Type 2 diabetic patients with nephropathy</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>Leptin plays an important role in the regulation of body weight and energy balance. Women have higher circulating leptin level than men. In this study, we examined serum leptin concentrations in Type 2 diabetic men and women with or without nephropathy. Fasting plasma glucose (FPG), lipid profile, and serum leptin concentrations were measured in 34 Type 2 diabetic patients with nephropathy (DMN), 12 normoalbuminuric Type 2 diabetic subjects (DM) and 34 non-diabetic control subjects, all matched for age and body mass index (BMI).
Result: Patients with diabetic nephropathy had lower high-density lipoprotein cholesterol and higher triglyceride, FPG, urinary albumin/creatinine ratio (ACR) and serum creatinine than the other two groups. There was a significant trend in serum leptin concentrations (
P<0.001, analysis of variance ANOVA) across the three groups with the main difference being detected between DMN and control subjects (DMN: 17.5±16.8
ng/ml, DM: 14.6±10.5
ng/ml and control: 9.1±7.1
ng/ml). Women had higher serum leptin concentration than men in the control group (12.5±7.3
ng/ml versus 4.2±2.0
ng/ml,
P=0.001) and in the DM group (18.9±11
ng/ml versus 8.6±5.9
ng/ml,
P=0.07) whereas this gender difference was not observed in the DMN group (18.6±17.0
ng/ml versus 16.8±17.0
ng/ml,
P=0.754). On multivariate analysis, ACR (
β=0.411,
P<0.001) and BMI (
β=0.240,
P=0.002) were independently associated with serum leptin concentrations (
R
2=0.194,
F=22.1,
P<0.001) in the whole group. In the DMN group, ACR (
β=0.370,
P=0.016) was the only independent determinant of serum leptin concentrations (
R
2=0.159,
F=11.4,
P=0.016). Serum leptin concentrations were higher in Type 2 diabetic patients with nephropathy than normoalbuminuric diabetic patients and controls. Diabetic men with nephropathy had proportionally higher serum leptin such that the gender difference in leptin observed in non-nephropathic individuals was abolished.</description><subject>Adult</subject><subject>Albuminuria - etiology</subject><subject>Analysis of Variance</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>Chinese</subject><subject>Creatinine - urine</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Diabetes Mellitus, Type 2 - urine</subject><subject>Diabetic Nephropathies - etiology</subject><subject>Diabetic nephropathy</subject><subject>Female</subject><subject>Gender</subject><subject>Humans</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osmolar Concentration</subject><subject>Sex Characteristics</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkE1PAyEQhonR2Fr9CRpO3lr5WpaejGn8aNLESz0TCrOW2rIrbDX997J2E4-emAzPywwPQteUTCih8m4zcd6sIqQJI4Tn3oQwfoKGVJVsrBgrT9Ewc-q3HqCLlDaEEMlFcY4GtMiVJHSINvNgI5gEDm-haX3Atg4WQhtN6-uQsAn5xtgPXFf4HYKDiJ2vKoiQMZz55aEBzHC3DbTe4iYHcz7hb9-ucYBmHevcWx8u0Vlltgmu-nOE3p4el7OX8eL1eT57WIwtl7Qdy2nBLScro5TgJZWi4LQQphLWulLQgivBrDSOCFAArLJ0ygQUSkpiHS05H6Hb47tNrD_3kFq988nCdmsC1PukS1pOS6JIBosjaGOdUoRKN9HvTDxoSnQnWW90L1l3krt2lpxzN_2A_WoH7i_VW83A_RGA_M0vD1En6ztfzkewrXa1_2fED590kIM</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Chan, W.B.</creator><creator>Ma, R.C.W.</creator><creator>Chan, N.N.</creator><creator>Ng, M.C.Y.</creator><creator>Lee, Z.S.K.</creator><creator>Lai, C.W.K.</creator><creator>Tong, P.C.Y.</creator><creator>So, W.Y.</creator><creator>Chan, J.C.N.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Increased leptin concentrations and lack of gender difference in Type 2 diabetic patients with nephropathy</title><author>Chan, W.B. ; Ma, R.C.W. ; Chan, N.N. ; Ng, M.C.Y. ; Lee, Z.S.K. ; Lai, C.W.K. ; Tong, P.C.Y. ; So, W.Y. ; Chan, J.C.N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-6953c30ba8843716453154af4ccd74153842c6ad04e8ee2fc1924e58660cd1733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Albuminuria - etiology</topic><topic>Analysis of Variance</topic><topic>Body Mass Index</topic><topic>Case-Control Studies</topic><topic>Chinese</topic><topic>Creatinine - urine</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - pathology</topic><topic>Diabetes Mellitus, Type 2 - urine</topic><topic>Diabetic Nephropathies - etiology</topic><topic>Diabetic nephropathy</topic><topic>Female</topic><topic>Gender</topic><topic>Humans</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Osmolar Concentration</topic><topic>Sex Characteristics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, W.B.</creatorcontrib><creatorcontrib>Ma, R.C.W.</creatorcontrib><creatorcontrib>Chan, N.N.</creatorcontrib><creatorcontrib>Ng, M.C.Y.</creatorcontrib><creatorcontrib>Lee, Z.S.K.</creatorcontrib><creatorcontrib>Lai, C.W.K.</creatorcontrib><creatorcontrib>Tong, P.C.Y.</creatorcontrib><creatorcontrib>So, W.Y.</creatorcontrib><creatorcontrib>Chan, J.C.N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, W.B.</au><au>Ma, R.C.W.</au><au>Chan, N.N.</au><au>Ng, M.C.Y.</au><au>Lee, Z.S.K.</au><au>Lai, C.W.K.</au><au>Tong, P.C.Y.</au><au>So, W.Y.</au><au>Chan, J.C.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased leptin concentrations and lack of gender difference in Type 2 diabetic patients with nephropathy</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>64</volume><issue>2</issue><spage>93</spage><epage>98</epage><pages>93-98</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>Leptin plays an important role in the regulation of body weight and energy balance. Women have higher circulating leptin level than men. In this study, we examined serum leptin concentrations in Type 2 diabetic men and women with or without nephropathy. Fasting plasma glucose (FPG), lipid profile, and serum leptin concentrations were measured in 34 Type 2 diabetic patients with nephropathy (DMN), 12 normoalbuminuric Type 2 diabetic subjects (DM) and 34 non-diabetic control subjects, all matched for age and body mass index (BMI).
Result: Patients with diabetic nephropathy had lower high-density lipoprotein cholesterol and higher triglyceride, FPG, urinary albumin/creatinine ratio (ACR) and serum creatinine than the other two groups. There was a significant trend in serum leptin concentrations (
P<0.001, analysis of variance ANOVA) across the three groups with the main difference being detected between DMN and control subjects (DMN: 17.5±16.8
ng/ml, DM: 14.6±10.5
ng/ml and control: 9.1±7.1
ng/ml). Women had higher serum leptin concentration than men in the control group (12.5±7.3
ng/ml versus 4.2±2.0
ng/ml,
P=0.001) and in the DM group (18.9±11
ng/ml versus 8.6±5.9
ng/ml,
P=0.07) whereas this gender difference was not observed in the DMN group (18.6±17.0
ng/ml versus 16.8±17.0
ng/ml,
P=0.754). On multivariate analysis, ACR (
β=0.411,
P<0.001) and BMI (
β=0.240,
P=0.002) were independently associated with serum leptin concentrations (
R
2=0.194,
F=22.1,
P<0.001) in the whole group. In the DMN group, ACR (
β=0.370,
P=0.016) was the only independent determinant of serum leptin concentrations (
R
2=0.159,
F=11.4,
P=0.016). Serum leptin concentrations were higher in Type 2 diabetic patients with nephropathy than normoalbuminuric diabetic patients and controls. Diabetic men with nephropathy had proportionally higher serum leptin such that the gender difference in leptin observed in non-nephropathic individuals was abolished.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>15063601</pmid><doi>10.1016/j.diabres.2003.10.023</doi><tpages>6</tpages></addata></record> |
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| language | eng |
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| source | ScienceDirect Journals |
| subjects | Adult Albuminuria - etiology Analysis of Variance Body Mass Index Case-Control Studies Chinese Creatinine - urine Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - urine Diabetic Nephropathies - etiology Diabetic nephropathy Female Gender Humans Leptin Leptin - blood Male Middle Aged Osmolar Concentration Sex Characteristics |
| title | Increased leptin concentrations and lack of gender difference in Type 2 diabetic patients with nephropathy |
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