Aqueous starch acetate dispersion as a novel coating material for controlled release products

The aim of this study was to evaluate film-formation properties of a novel, organic solvent-free aqueous dispersion of potato starch acetate (SA; degree of substitution 2.8) and its ability to control drug release from a coated tablet. Initially, film-formation mechanisms and drug permeabilities of...

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Bibliographic Details
Published in:Journal of controlled release 2004-04, Vol.96 (1), p.179-191
Main Authors: Tarvainen, Maarit, Peltonen, Soili, Mikkonen, Hannu, Elovaara, Minna, Tuunainen, Minna, Paronen, Petteri, Ketolainen, Jarkko, Sutinen, Riitta
Format: Article
Language:English
Subjects:
Biological and medical sciences
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - pharmacokinetics
Coating
Controlled release
Delayed-Action Preparations - chemistry
Delayed-Action Preparations - pharmacokinetics
Dispersion
Free film
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Solanum tuberosum
Starch - analogs & derivatives
Starch - chemistry
Starch - pharmacokinetics
Starch acetate
Water - chemistry
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Summary:The aim of this study was to evaluate film-formation properties of a novel, organic solvent-free aqueous dispersion of potato starch acetate (SA; degree of substitution 2.8) and its ability to control drug release from a coated tablet. Initially, film-formation mechanisms and drug permeabilities of both organic solvent and dispersion-based SA free films (prepared by cast or spraying techniques) were investigated. The SA dispersion was suitable for the fluid-bed coating process, forming strong films with complete coalescent polymeric spheres. The model compounds predominantly permeated via the micro-pores of SA free films, which resulted from the leaching of water-soluble excipients from the dispersion. Thus, the permeation rate depended on the film structure rather than the physico-chemical properties of the penetrant. In the case of SA-coated tablet, drug release was sustained when the coating level was increased (from 12% to 20%, stated as a weight gain), and also as lipophilicity of the drug increased. When compared to the reference polymer dispersion (Surelease®), SA coatings showed better mechanical properties against the osmotic pressure caused by a hydrophilic core tablet. These results clearly demonstrate that SA dispersion has high utility as a novel aqueous coating material for controlled release products.
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2004.01.016