Molecularly imprinted polymers: towards highly selective stationary phases in liquid chromatography and capillary electrophoresis

Molecularly imprinted polymers (MIPs) are synthetic polymers with a predetermined selectivity for a given analyte, or group of structurally related compounds, that make them ideal materials to be used in separation processes. In this sense, it is not surprising that the first applications of MIPs we...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2004-04, Vol.378 (8), p.1876-1886
Main Authors: Turiel, E, Martin-Esteban, A
Format: Article
Language:English
Subjects:
Binding Sites
Biomimetic Materials - chemical synthesis
Biomimetic Materials - chemistry
Chromatography, Liquid - instrumentation
Electrophoresis, Capillary - instrumentation
Polymers - chemical synthesis
Polymers - chemistry
Sensitivity and Specificity
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Summary:Molecularly imprinted polymers (MIPs) are synthetic polymers with a predetermined selectivity for a given analyte, or group of structurally related compounds, that make them ideal materials to be used in separation processes. In this sense, it is not surprising that the first applications of MIPs were as tailor-made chiral stationary phases in liquid chromatography. However, peak broadening and tailing, especially of the more retained enantiomers, were observed. Accordingly, this paper gives an overview of the attempts carried out during the recent years to improve the chromatographic performance of MIPs in liquid chromatography and capillary electrophoresis as well as the more recent applications. We conclude that MIPs are very promising materials to be used as selective stationary phases in chromatography although further developments are necessary in order to fully exploit their potential.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-003-2331-1