Overlapping expression pattern of the actin organizers Spir-1 and formin-2 in the developing mouse nervous system and the adult brain

The Wiskott–Aldrich homology domain 2 (WH2) family protein Spir and the formin Cappuccino belong to two distinct classes of actin organizers. Despite their functional classification as actin organizers, a major defect of Drosophila spire and cappuccino mutant oocytes is a failure in the orientation...

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Bibliographic Details
Published in:Gene Expression Patterns 2004-05, Vol.4 (3), p.249-255
Main Authors: Schumacher, Nina, Borawski, Johanna M, Leberfinger, Cornelia B, Gessler, Manfred, Kerkhoff, Eugen
Format: Article
Language:English
Subjects:
Actin
Actins - metabolism
Animals
Brain
Brain - metabolism
Cappuccino
Carrier Proteins - genetics
Cytoskeleton
Drosophila Proteins - genetics
Formin-2
In Situ Hybridization
Mice - embryology
Mice - genetics
Mice - metabolism
Microfilament Proteins - biosynthesis
Microfilament Proteins - genetics
Nerve Tissue Proteins - biosynthesis
Nerve Tissue Proteins - genetics
Nervous system
Nervous System - embryology
Nervous System - metabolism
Oligoribonucleotides, Antisense - genetics
Protein Structure, Tertiary
Purkinje Cells - metabolism
Spir-1
Spire
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Summary:The Wiskott–Aldrich homology domain 2 (WH2) family protein Spir and the formin Cappuccino belong to two distinct classes of actin organizers. Despite their functional classification as actin organizers, a major defect of Drosophila spire and cappuccino mutant oocytes is a failure in the orientation of microtubule plus ends towards the posterior pole. Mammalian homologues of spire are the spir-1 and spir-2 genes. The mouse and human formin-1 and formin-2 genes have high similarity to the cappuccino gene. The mouse formin-2 gene has been found to be expressed in the developing nervous system and in neuronal cells of the adult brain. By analyzing the expression of the spir-1 gene we show that spir-1 and formin-2 have a nearly identical expression pattern during mouse embryogenesis and in the adult brain. In mouse embryos both genes are expressed in the developing nervous system. In the adult brain high expression of the genes was found in the Purkinje cells of the cerebellum and in neuronal cells of the hippocampus and dentate gyrus.
ISSN:1567-133X
1872-7298
DOI:10.1016/j.modgep.2003.11.006