Ceruloplasmin metabolism and function

Ceruloplasmin is a serum ferroxidase that contains greater than 95% of the copper found in plasma. This protein is a member of the multicopper oxidase family, an evolutionarily conserved group of proteins that utilize copper to couple substrate oxidation with the four-electron reduction of oxygen to...

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Bibliographic Details
Published in:Annual review of nutrition 2002-01, Vol.22, p.439-458
Main Authors: HELLMAN, Nathan E, GITLIN, Jonathan D
Format: Article
Language:English
Subjects:
Biological and medical sciences
Ceruloplasmin - deficiency
Ceruloplasmin - genetics
Ceruloplasmin - metabolism
Ceruloplasmin - physiology
Copper
Copper - metabolism
Copper - physiology
Errors of metabolism
Humans
Iron
Iron - metabolism
Medical sciences
Metabolic diseases
Neurodegenerative Diseases - diagnosis
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - metabolism
Oxidation-Reduction
Proteins and glycoproteins
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Summary:Ceruloplasmin is a serum ferroxidase that contains greater than 95% of the copper found in plasma. This protein is a member of the multicopper oxidase family, an evolutionarily conserved group of proteins that utilize copper to couple substrate oxidation with the four-electron reduction of oxygen to water. Despite the need for copper in ceruloplasmin function, this protein plays no essential role in the transport or metabolism of this metal. Aceruloplasminemia is a neurodegenerative disease resulting from inherited loss-of-function mutations in the ceruloplasmin gene. Characterization of this disorder revealed a critical physiological role for ceruloplasmin in determining the rate of iron efflux from cells with mobilizable iron stores and has provided new insights into human iron metabolism and nutrition.
ISSN:0199-9885
1545-4312
DOI:10.1146/annurev.nutr.22.012502.114457