Androgen receptor protein expression in prostatic tissues in black and caucasian men

• Published in: The Prostate 2004-06, Vol.59 (4), p.460-468
• Main Authors: Olapade-Olaopa, E. Oluwabunmi, Muronda, Charles A., MacKay, E. Hugh, Danso, Alex P., Sandhu, Davinder P., Terry, Timothy R., Habib, Fouad K.
• Format: Article
• Language: English
• Subjects: African Continental Ancestry Group; androgen receptor; Biological and medical sciences; Black; BPH; Case-Control Studies; Caucasian; European Continental Ancestry Group; Gynecology. Andrology. Obstetrics; Humans; Male; Male genital diseases; Medical sciences; Nephrology. Urinary tract diseases; Prostate - physiology; prostate cancer; Prostatic Hyperplasia - genetics; Prostatic Hyperplasia - physiopathology; Prostatic Neoplasms - genetics; Prostatic Neoplasms - physiopathology; Receptors, Androgen - biosynthesis; stromal-epithelial interaction; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland
• ISSN: 0270-4137; 1097-0045
• DOI: 10.1002/pros.20014

BACKGROUND CaP has a higher incidence and mortality in Black men. We hypothesized that subpopulation differences in AR expression may contribute to this phenomenon. METHOD AR immunostaining was compared in epithelium and PES of normal, BPH, and CaP tissues from Black African men and UK Caucasian men. RESULTS AR expression was similar in normal prostatic epithelium of both groups, but was higher in BPH and CaP epithelium of Black than Caucasian men (P ≤ 0.0001). Also, AR expression in PES was higher in Caucasian than Black men in normal/atrophic and benign hyperplastic tissues, but there was a similar significant loss of AR expression in PES of CaP tissues of both groups (normal and BPH stroma versus CaP stroma (P ≤ 0.0001). CONCLUSIONS Variations in AR expression between subpopulations may contribute to the phenotypic differences of prostatic diseases in Black and Caucasian men. © 2004 Wiley‐Liss, Inc.