One-trial tolerance to the effects of chlordiazepoxide in the elevated plus-maze is not due to acquisition of a phobic avoidance of open arms during initial exposure

A single exposure to the elevated plus-maze (EPM) test of anxiety reduces or abolishes the anxiolytic-like efficacy of benzodiazepines. This phenomenon called one-trial tolerance has been suggested to represent the acquisition of a phobic-like response to the open arms during trial 1. The present st...

Full description

Saved in:
Bibliographic Details
Published in:Life sciences (1973) 2002-06, Vol.71 (5), p.519-525
Main Authors: Frussa-Filho, R., Ribeiro, R.de A.
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Anti-Anxiety Agents - pharmacology
Anxiety
Anxiety - drug therapy
Behavior, Animal - drug effects
Chlordiazepoxide
Chlordiazepoxide - pharmacology
Drug Tolerance
Elevated plus-maze
Male
Maze Learning
Phobia
Phobic Disorders
Random Allocation
Rats
Rats, Wistar
Tolerance
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A single exposure to the elevated plus-maze (EPM) test of anxiety reduces or abolishes the anxiolytic-like efficacy of benzodiazepines. This phenomenon called one-trial tolerance has been suggested to represent the acquisition of a phobic-like response to the open arms during trial 1. The present study was designed to examine the effects of chlordiazepoxide (5 mg/kg, ip) on the behaviour of rats in a conventional EPM apparatus after previous exposure to a four-open-arm EPM, a four-enclosed arm EPM or a conventional EPM, as well as in naive rats. Chlordiazepoxide had clear-cut anxiolytic-like effects (increased percentage of time spent on the open arms) in a traditional EPM in naive rats and in animals previously exposed to a four-open-arm EPM. However, it was ineffective in rats previously exposed to a traditional or a four-closed-arm EPM. Thus, the phenomenon of one-trial tolerance does not depend upon initial open-arm experience.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(02)01709-5