Regional delivery of vancomycin using pluronic F-127 to inhibit methicillin resistant Staphylococcus aureus (MRSA) growth in chronic otitis media in vitro and in vivo

For the effective treatment of chronic otitis media caused by methicillin resistant Staphylococcus aureus (MRSA), the local delivery of vancomycin was attempted based on a formulation with pluronic F-127. The phase transition property of pluronic F-127, which is liquid at room temperature and become...

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Bibliographic Details
Published in:Journal of controlled release 2004-04, Vol.96 (1), p.1-7
Main Authors: Lee, Sang Heun, Lee, Ji Eun, Baek, Woon Yi, Lim, Jeong Ok
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chronic Disease
Chronic otitis media
Drug Delivery Systems - methods
General pharmacology
Gerbillinae
Medical sciences
Methicillin Resistance - drug effects
Methicillin Resistance - physiology
MRSA, methicillin resistant Staphylococcus aureus
Otitis Media - drug therapy
Otitis Media - pathology
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pluronic F-127
Poloxamer - administration & dosage
Poloxamer - pharmacokinetics
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - growth & development
Thermoreversible gel
Vancomycin
Vancomycin - administration & dosage
Vancomycin - pharmacokinetics
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Summary:For the effective treatment of chronic otitis media caused by methicillin resistant Staphylococcus aureus (MRSA), the local delivery of vancomycin was attempted based on a formulation with pluronic F-127. The phase transition property of pluronic F-127, which is liquid at room temperature and becomes solid at body temperature, enabled convenient injection and reduced the side effects of the potent antibiotic. The temperature responsive polymer–vancomycin matrix system was also shown to effectively deliver vancomycin locally to the infected inner ear, plus the MRSA growth was inhibited by the formulation. The otitis media was completely cured by the sustained local delivery of vancomycin from the matrix in vivo. Accordingly, this system has potential clinical application for treating chronic otitis media with improved patient compliance and better therapeutic efficacy.
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2003.12.029