Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors

Objectives: To assess the relationship between poor oral health and coronary heart disease (CHD) and systemic inflammatory and haemostatic factors in an Italian population. Material and Methods: The study population consisted of 63 males aged 40–65 years with proven CHD and 50 controls matched for a...

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Published in:Journal of clinical periodontology 2004-01, Vol.31 (1), p.25-29
Main Authors: Montebugnoli, L., Servidio, D., Miaton, R.A., Prati, C., Tricoci, P., Melloni, C.
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Coagulation Factors - analysis
C-Reactive Protein - analysis
cardiovascular disease
Case-Control Studies
Cholesterol - blood
Coronary Disease - blood
Coronary Disease - complications
Dentistry
epidemiology
Fibrinogen - analysis
Humans
Inflammation Mediators - analysis
Italy
Leukocyte Count
Male
Middle Aged
odds ratio
Peptide Fragments - analysis
periodontal disease
Periodontal Diseases - blood
Periodontal Diseases - complications
Periodontal Index
Prothrombin - analysis
Radiography, Panoramic
risk factor
Statistics, Nonparametric
Tooth Diseases - blood
Tooth Diseases - complications
Triglycerides - blood
von Willebrand Factor - analysis
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Summary:Objectives: To assess the relationship between poor oral health and coronary heart disease (CHD) and systemic inflammatory and haemostatic factors in an Italian population. Material and Methods: The study population consisted of 63 males aged 40–65 years with proven CHD and 50 controls matched for age, geographic area, and socioeconomic status. A detailed description of their oral status was given using four different dental indices (total dental index (TDI), panoramic tomography score, clinical periodontal sum score (CPSS), and clinical and radiographic sum score (CRSS)). Blood samples were taken for measurement of the following CHD risk factors: serum total cholesterol, triglycerides, high‐density lipoprotein (HDL) cholesterol, low‐density lipoprotein (LDL) cholesterol, and glucose; a series of systemic markers of inflammation (C‐reactive protein, leucocytes, fibrinogen, homocysteine) and a series of haemostatic factors (von Willebrand factor, fibrin d‐dimer, prothrombinic fragment F1.2, plasminogen activator inhibitor type I (PAI‐1), and serum antibodies) against oxidized LDL (anti‐Ox‐LDL). Results: Multiple logistic regression adjusted for all risk factors for CHD showed statistically significant relationships (p
ISSN:0303-6979
1600-051X
DOI:10.1111/j.0303-6979.2004.00432.x