The interleukin 1 receptor family

Interleukin-1 is a key inflammatory cytokine that mediates its effects through a type I receptor and a receptor accessory protein. These two molecules are members of a wider family of proteins that have in common the presence of immunoglobulin domains in the extracellular region of the protein and a...

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Bibliographic Details
Published in:Developmental and comparative immunology 2004-05, Vol.28 (5), p.415-428
Main Authors: Subramaniam, Sumathi, Stansberg, Christine, Cunningham, Charles
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Cytokine
Evolution, Molecular
Humans
Interleukin-1
Interleukin-1 receptor
Interleukin-1 Receptor Accessory Protein
Interleukin-1 Receptor-Like 1 Protein
Interleukin-18 Receptor alpha Subunit
Membrane Glycoproteins - classification
Membrane Glycoproteins - genetics
Membrane Glycoproteins - physiology
Membrane Proteins - genetics
Membrane Proteins - physiology
Models, Immunological
Molecular Sequence Data
Multigene Family
Phylogeny
Proteins - classification
Proteins - genetics
Proteins - physiology
Receptors, Cell Surface - classification
Receptors, Cell Surface - genetics
Receptors, Cell Surface - physiology
Receptors, Interleukin - genetics
Receptors, Interleukin - physiology
Receptors, Interleukin-1 - classification
Receptors, Interleukin-1 - genetics
Receptors, Interleukin-1 - physiology
Receptors, Interleukin-18
Sequence Homology, Amino Acid
Signal Transduction
Toll
Toll like receptor
Toll-Like Receptors
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Description
Summary:Interleukin-1 is a key inflammatory cytokine that mediates its effects through a type I receptor and a receptor accessory protein. These two molecules are members of a wider family of proteins that have in common the presence of immunoglobulin domains in the extracellular region of the protein and a TIR domain in the cytoplasmic region. The nature of this family of proteins and their signal transduction pathway is discussed in this review.
ISSN:0145-305X
1879-0089
DOI:10.1016/j.dci.2003.09.016