Topical analgesics and blood pressure during static contraction in humans

• Published in: Medicine and science in sports and exercise 2004-04, Vol.36 (4), p.632-638
• Main Authors: DAWSON, Alison N, WALSER, Buddy, JAFARZADEH, Mehrdad, STEBBINS, Charles L
• Format: Article
• Language: English
• Subjects: Administration, Topical; Adult; Analgesics - administration & dosage; Analgesics - pharmacology; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood Pressure - drug effects; California; Capsaicin - administration & dosage; Capsaicin - pharmacology; Female; Forearm - blood supply; Forearm - physiology; Heart Rate - drug effects; Humans; Local anesthesia. Pain (treatment); Male; Medical sciences; Middle Aged; Muscle Contraction - drug effects; Muscle Contraction - physiology; Muscle, Skeletal - drug effects; Muscle, Skeletal - physiology; Physical Exertion - drug effects; Physical Exertion - physiology; Regional Blood Flow - drug effects; Salicylates - administration & dosage; Salicylates - pharmacology; Space life sciences
• ISSN: 0195-9131; 1530-0315
• DOI: 10.1249/01.MSS.0000121949.43010.F4

In decerebrate cats, topical application of analgesic balm (AB) can attenuate the pressor response to electrically induced static contraction. We examined the possibility that this phenomenon also occurs in humans and determined whether such effects were limited to a local action on the contracting muscle (e.g., attenuations of the action of groups III and IV muscle afferents that cause the exercise pressor reflex) or whether they also may have affected active muscle blood flow and/or central command. Blood pressure (mean arterial pressure (MAP)), heart rate (HR), brachial artery blood flow (BABF), and relative perceived exertion (RPE) were assessed at rest and during 90 s of static handgrip contraction before and 50 min after application of a commercially available AB (1% capsaicin, 12.5% methyl salicylate) to the skin of the forearm muscles. AB attenuated the MAP response to contraction (19 +/- 3 vs 27 +/- 5 mm Hg) but had no effect on the HR response. Absolute BABF was enhanced at rest and during contraction, but absolute (118 +/- 47 vs 114 +/- 47 mL x min) and percent increases (83 +/- 31 vs 55 +/-19%) were not statistically different between conditions. AB appeared to slightly enhance RPE, but this was also the case in a control protocol where only the vehicle (petroleum jelly) was used and no change in the blood pressure response was seen. AB attenuates contraction-induced increases in MAP that do not seem to be related to alterations in perfusion of active muscle or central command. Effects appear to be localized to the active skeletal muscle and likely involve reductions in sensitivity of groups III and IV muscle afferents to local chemical and/or mechanical stimulation.