Hypertrophy of the heart: A new therapeutic target?

Recent studies call into question the necessity of hypertrophic growth of the heart as a "compensatory" response to hemodynamic stress. These findings, coupled with recent progress in dissecting the molecular bases of hypertrophy, raise the prospect of suppressing hypertrophy without provo...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2004-04, Vol.109 (13), p.1580-1589
Main Authors: FREY, Norbert, KATUS, Hugo A, OLSON, Eric N, HILL, Joseph A
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animals
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - prevention & control
Biological and medical sciences
Blood and lymphatic vessels
Calcium - physiology
Cardiac Output
Cardiology. Vascular system
Cardiovascular Agents - therapeutic use
Cell Size
Clinical Trials as Topic
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Heart Diseases - complications
Heart Diseases - physiopathology
Heart Failure - etiology
Heart Failure - prevention & control
Humans
Hypertrophy, Left Ventricular - drug therapy
Hypertrophy, Left Ventricular - etiology
Hypertrophy, Left Ventricular - metabolism
Hypertrophy, Left Ventricular - physiopathology
Ion Channels - physiology
Mechanoreceptors - physiology
Medical sciences
Muscle Proteins - physiology
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Pressure
Ventricular Remodeling - drug effects
Ventricular Remodeling - physiology
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Summary:Recent studies call into question the necessity of hypertrophic growth of the heart as a "compensatory" response to hemodynamic stress. These findings, coupled with recent progress in dissecting the molecular bases of hypertrophy, raise the prospect of suppressing hypertrophy without provoking circulatory insufficiency. In this article, we focus on signaling pathways that hold promise as potential targets for therapeutic intervention. We also summarize observations from animal models and clinical trials that suggest benefit from an antihypertrophic strategy.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000120390.68287.BB