Marek's Disease in Turkeys. I. A Seven-Year Survey of Commercial Flocks and Experimental Infection Using Two Field Isolates

Marek's disease virus (MDV) causes immunosuppression and tumors in chickens, but the turkey is an unusual host for the virus, and tumors caused by MDV in turkeys are unique. We describe the prevalence of turkey tumors in Israel between 1993 and 2000, their molecular diagnosis by polymerase chai...

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Bibliographic Details
Published in:Avian diseases 2002-04, Vol.46 (2), p.314-321
Main Authors: Davidson, Irit, Malkinson, M, Weisman, Y
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - analysis
Chickens
Diagnosis, Differential
Disease Outbreaks - veterinary
disease prevalence
disease reproduction
DNA, Viral - blood
DNA, Viral - isolation & purification
Enzyme-Linked Immunosorbent Assay - veterinary
experimental infections
Flocks
Gallid herpesvirus 2
Herpesvirus 2, Gallid - genetics
Herpesvirus 2, Gallid - immunology
Herpesvirus 2, Gallid - isolation & purification
Herpesvirus 2, Gallid - pathogenicity
hosts
Infections
Israel - epidemiology
Kidney - virology
Liver - virology
Mardivirus
Marek disease
Marek Disease - diagnosis
Marek Disease - epidemiology
Marek Disease - pathology
Marek's disease
neoplasms
Polymerase chain reaction
Polymerase Chain Reaction - methods
Polymerase Chain Reaction - veterinary
Prevalence
Regular s
Spleen - virology
strain differences
strains
surveys
Tumors
Turkeys
Vaccination
Viral diseases
Virulence
Viruses
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Description
Summary:Marek's disease virus (MDV) causes immunosuppression and tumors in chickens, but the turkey is an unusual host for the virus, and tumors caused by MDV in turkeys are unique. We describe the prevalence of turkey tumors in Israel between 1993 and 2000, their molecular diagnosis by polymerase chain reaction (PCR), and the natural distribution of herpesvirus of turkeys (HVT). Most clinical cases with tumors in commercial turkeys were diagnosed as MDV. The reproduction of Marek's disease (MD) in turkeys by two turkey MDV strains, Ar and La, was analyzed, and it was shown that these strains can induce tumors in experimental trials. The severity of experimental disease differed from those features of the original outbreak, since a less severe disease was recorded.
ISSN:0005-2086
1938-4351
DOI:10.1637/0005-2086(2002)046[0314:MSDITI]2.0.CO;2