Specific airway resistance in 3-year-old children: a prospective cohort study

• Published in: The Lancet (British edition) 2002-06, Vol.359 (9321), p.1904-1908
• Main Authors: Lowe, Lesley, Murray, Clare S, Custovic, Adnan, Simpson, Bridget M, Kissen, Patricia M, Woodcock, Ashley
• Format: Article
• Language: English
• Subjects: Airway Resistance - genetics; Asthma; Asthma - etiology; Asthma - genetics; Atopy; Biological and medical sciences; Child, Preschool; Children; Children & youth; Cohort analysis; Female; Health risk assessment; Humans; Lungs; Male; Masks; Medical sciences; Mothers; Parents; Parents & parenting; Plethysmography; Pneumology; Prospective Studies; Respiratory diseases; Respiratory function; Respiratory Sounds; Respiratory system : syndromes and miscellaneous diseases; Respiratory tract; Risk analysis; Risk Factors; Risk groups; Skin; Skin Tests; Smoking - adverse effects; Statistical analysis; Variance analysis
• ISSN: 0140-6736; 1474-547X
• DOI: 10.1016/S0140-6736(02)08781-0

The development of a method to assess lung function in young children may provide new insight into asthma development. Plethysmographic measurement of specific airway resistance (sRaw) is feasible in this age group. We aimed to identify risk factors associated with low lung function in early childhood in a prospective birth cohort. Children were prenatally assigned to risk group according to parental atopic status (high risk, both parents atopic; medium risk, one parent atopic; low risk, neither parent atopic) and followed prospectively until age 3 years. We measured sRaw in 503 symptom-free children using whole-body plethysmography during tidal breathing. 803 of 868 children attended the clinic, of whom 503 obtained satisfactory sRaw readings. 200 who wheezed at least once during first 3 years of life had significantly higher sRaw than the 303 who had never wheezed (mean difference 5·8%, 95% CI 2·2–9·3, p=0·002). For children who had never wheezed there were significant differences in sRaw between risk groups (p