Usefulness of 201Tl and 99mTc MIBI scintigraphy in a case of oncogenic osteomalacia

A 45-year-old male was admitted with difficulty in walking due to leg pain. At the time of the first visit, a reduced serum phosphorus concentration and an increased serum alkaline phosphatase concentration of unknown etiology were observed. Either a whole body bone scintigraphy or CT of the neck, c...

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Bibliographic Details
Published in:Annals of nuclear medicine 2004-02, Vol.18 (1), p.63-67
Main Authors: Kimizuka, Takao, Ozaki, Yutaka, Sumi, Yukiharu
Format: Article
Language:English
Subjects:
Hemangiopericytoma - diagnosis
Hemangiopericytoma - diagnostic imaging
Humans
Knee Joint - diagnostic imaging
Male
Middle Aged
Neoplasms, Adipose Tissue - diagnosis
Neoplasms, Adipose Tissue - diagnostic imaging
Osteomalacia - diagnosis
Osteomalacia - diagnostic imaging
Paraneoplastic Syndromes - diagnosis
Paraneoplastic Syndromes - diagnostic imaging
Radionuclide Imaging
Radiopharmaceuticals
Technetium Tc 99m Sestamibi
Thallium
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Summary:A 45-year-old male was admitted with difficulty in walking due to leg pain. At the time of the first visit, a reduced serum phosphorus concentration and an increased serum alkaline phosphatase concentration of unknown etiology were observed. Either a whole body bone scintigraphy or CT of the neck, chest and abdominal region did not reveal any underlying disease. However both the whole body 201Tl scintigraphy and 99mTc MIBI SPECT showed accumulation in the right knee region, and a small tumor was detected by MRI examination. After a diagnosis of oncogenic osteomalacia due to this tumor was determined the tumor was surgically removed, and turned out to be a hemangiopericytoma. By removal of the tumor, either the symptoms or the laboratory data were improved significantly. In this case, both 201Tl scintigraphy and 99mTc scintigraphy MIBI were useful in identifying the location of the tumor which caused oncogenic osteomalacia.
ISSN:0914-7187