Activation of Integrin Function by Nanopatterned Adhesive Interfaces

Sticky dots: To study the function behind the molecular arrangement of single integrins in cell adhesion, the authors designed a hexagonally close‐packed rigid template of cell adhesive gold nanodots by means of micellar diblock copolymer lithography. A critical separation length of ≥73 nm between t...

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Bibliographic Details
Published in:Chemphyschem 2004-03, Vol.5 (3), p.383-388
Main Authors: Arnold, Marco, Cavalcanti-Adam, Elisabetta Ada, Glass, Roman, Blümmel, Jacques, Eck, Wolfgang, Kantlehner, Martin, Kessler, Horst, Spatz, Joachim P.
Format: Article
Language:English
Subjects:
Biological and medical sciences
cell adhesion
Cell Adhesion - physiology
Cell Adhesion Molecules - chemistry
Cell Adhesion Molecules - metabolism
Cell interactions, adhesion
Cells, Cultured
Fibronectins - chemistry
Fundamental and applied biological sciences. Psychology
Gold - chemistry
integrin
Integrins - chemistry
Integrins - metabolism
Ligands
Micelles
Molecular and cellular biology
nanopatterning
Nanotechnology - instrumentation
Nanotechnology - methods
Peptides - chemistry
self-assembly
Stress Fibers - metabolism
surfaces
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Summary:Sticky dots: To study the function behind the molecular arrangement of single integrins in cell adhesion, the authors designed a hexagonally close‐packed rigid template of cell adhesive gold nanodots by means of micellar diblock copolymer lithography. A critical separation length of ≥73 nm between the adhesive dots dramatically reduces cell functions due to restricted integrin clustering (see picture). The range between 58–73 nm is proposed to be a universal length scale for integrin clustering and activation, since these properties are shared by a variety of cultured cells lines.
ISSN:1439-4235
1439-7641
DOI:10.1002/cphc.200301014