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Activation of Integrin Function by Nanopatterned Adhesive Interfaces

Sticky dots: To study the function behind the molecular arrangement of single integrins in cell adhesion, the authors designed a hexagonally close‐packed rigid template of cell adhesive gold nanodots by means of micellar diblock copolymer lithography. A critical separation length of ≥73 nm between t...

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Published in:	Chemphyschem 2004-03, Vol.5 (3), p.383-388
Main Authors:	Arnold, Marco, Cavalcanti-Adam, Elisabetta Ada, Glass, Roman, Blümmel, Jacques, Eck, Wolfgang, Kantlehner, Martin, Kessler, Horst, Spatz, Joachim P.
Format:	Article
Language:	English
Subjects:	Biological and medical sciences cell adhesion Cell Adhesion - physiology Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - metabolism Cell interactions, adhesion Cells, Cultured Fibronectins - chemistry Fundamental and applied biological sciences. Psychology Gold - chemistry integrin Integrins - chemistry Integrins - metabolism Ligands Micelles Molecular and cellular biology nanopatterning Nanotechnology - instrumentation Nanotechnology - methods Peptides - chemistry self-assembly Stress Fibers - metabolism surfaces
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creator	Arnold, Marco Cavalcanti-Adam, Elisabetta Ada Glass, Roman Blümmel, Jacques Eck, Wolfgang Kantlehner, Martin Kessler, Horst Spatz, Joachim P.
description	Sticky dots: To study the function behind the molecular arrangement of single integrins in cell adhesion, the authors designed a hexagonally close‐packed rigid template of cell adhesive gold nanodots by means of micellar diblock copolymer lithography. A critical separation length of ≥73 nm between the adhesive dots dramatically reduces cell functions due to restricted integrin clustering (see picture). The range between 58–73 nm is proposed to be a universal length scale for integrin clustering and activation, since these properties are shared by a variety of cultured cells lines.
doi_str_mv	10.1002/cphc.200301014
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subjects	Biological and medical sciences cell adhesion Cell Adhesion - physiology Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - metabolism Cell interactions, adhesion Cells, Cultured Fibronectins - chemistry Fundamental and applied biological sciences. Psychology Gold - chemistry integrin Integrins - chemistry Integrins - metabolism Ligands Micelles Molecular and cellular biology nanopatterning Nanotechnology - instrumentation Nanotechnology - methods Peptides - chemistry self-assembly Stress Fibers - metabolism surfaces
title	Activation of Integrin Function by Nanopatterned Adhesive Interfaces
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