Minimal number of chromatographic test parameters for the characterisation of reversed-phase liquid chromatographic stationary phases

This paper focuses on the classification or differentiation of RP-HPLC columns based on measured chromatographic properties. A chemometric study has been conducted on a published data set consisting of 85 RP-HPLC columns and on a data set consisting of 47 self-tested columns. Principal component ana...

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Bibliographic Details
Published in:Journal of Chromatography A 2002-04, Vol.954 (1), p.99-114
Main Authors: Iványi, Tı́mea, Vander Heyden, Yvan, Visky, Dóra, Baten, Peggy, De Beer, Jacques, Lázár, István, Massart, D.L, Roets, Eugène, Hoogmartens, Jos
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Chromatography, High Pressure Liquid - instrumentation
Chromatography, High Pressure Liquid - methods
Exact sciences and technology
Hydrogen-Ion Concentration
Other chromatographic methods
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Summary:This paper focuses on the classification or differentiation of RP-HPLC columns based on measured chromatographic properties. A chemometric study has been conducted on a published data set consisting of 85 RP-HPLC columns and on a data set consisting of 47 self-tested columns. Principal component analysis enables determination of the number of parameters necessary for a rational differentiation. The results show that reducing the number of parameters for such differentiation still allows classification of the columns just as a higher number did. It is shown that three test parameters produce a classification similar to that obtained with five parameters.
ISSN:0021-9673
DOI:10.1016/S0021-9673(02)00166-8