The Relationship between Infant Airway Function, Childhood Airway Responsiveness, and Asthma

The relationship between reduced pulmonary function in early life and persistent wheeze (PW) in school-aged children remains uncertain. In this study, VmaxFRC was assessed at 1 month of age, and the presence of wheeze up to 11 years of age was prospectively identified. At 11 years of age, airway res...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2004-04, Vol.169 (8), p.921-927
Main Authors: Turner, Stephen W, Palmer, Lyle J, Rye, Peter J, Gibson, Neil A, Judge, Parveenjeet K, Cox, Moreen, Young, Sally, Goldblatt, Jack, Landau, Louis I, Le Souef, Peter N
Format: Article
Language:English
Subjects:
Age
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Asthma
Asthma - physiopathology
Biological and medical sciences
Bronchial Hyperreactivity - physiopathology
Child
Child, Preschool
Cohort Studies
Cross-Sectional Studies
Enrollments
Female
Functional Residual Capacity
Histamine
Humans
Infant
Intensive care medicine
Lung - physiopathology
Male
Medical sciences
Prognosis
Questionnaires
Respiratory Sounds - etiology
Respiratory Sounds - physiopathology
Risk Factors
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Summary:The relationship between reduced pulmonary function in early life and persistent wheeze (PW) in school-aged children remains uncertain. In this study, VmaxFRC was assessed at 1 month of age, and the presence of wheeze up to 11 years of age was prospectively identified. At 11 years of age, airway responsiveness (AR) to inhaled histamine and atopy were assessed. Recent wheeze at 11 years of age was associated with a reduced mean z score for VmaxFRC at 1 month of age (-0.41 [SD 0.91], n = 31) compared with no recent wheeze (0.04 [SD 1.00], n = 153, p = 0.03). Wheeze between 4 and 6 years that persisted at 11 years (PW) was most prevalent among those with reduced VmaxFRC at 1 month and atopy aged 11 years (p = 0.002) or reduced VmaxFRC and increased AR aged 11 years (p = 0.015). When all factors were considered, reduced VmaxFRC at 1 month (p = 0.03) and increased AR aged 11 years (p < 0.001) were independently associated with PW (n = 17) compared with other outcomes (n = 129). Reduced airway function present in early infancy is associated with PW at 11 years of age, and this relationship is independent of the effect of increased AR and atopy in childhood.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.200307-891OC