Effect of aging on brain energy-metabolism

The aging process involves morphological and functional changes in cerebral vasculature and deterioration of mitochondrial number and function. Furthermore, slow oscillations of cerebral blood flow and oxidative metabolism occur in animals under different pathological conditions such as ischemia. Th...

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Bibliographic Details
Published in:Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2002-05, Vol.132 (1), p.117-120
Main Authors: Zarchin, Nili, Meilin, Sigal, Rifkind, Joseph, Mayevsky, Avraham
Format: Article
Language:English
Subjects:
Aging - metabolism
Aging brain
Animals
Anoxia
Brain - blood supply
Brain - metabolism
Cerebral blood flow
Cerebrovascular Circulation
Energy Metabolism
Hypoxia - metabolism
Metabolic oscillations
Mitochondria - metabolism
Mitochondrial NADH
Multiparameter monitoring
NAD - metabolism
Oxygen - metabolism
Rats
Time Factors
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Summary:The aging process involves morphological and functional changes in cerebral vasculature and deterioration of mitochondrial number and function. Furthermore, slow oscillations of cerebral blood flow and oxidative metabolism occur in animals under different pathological conditions such as ischemia. The aim of this study was to evaluate the effect of aging on energy-metabolism of the rat brain during anoxia and normoxia and to further investigate the occurrence of oscillations under normoxia in the aging brain. Simultaneous hemodynamical (CBF), biochemical (NADH/NAD ratio) and electrical activity from the cerebral cortex were measured by means of a multiparametric assembly (MPA) system. Exposure of adult rats to anoxia (100% N 2) resulted in a 36±2% elevation of NADH. Furthermore, exposure of the aged group to anoxia caused NADH elevation as low as 9.6±4% ( P
ISSN:1095-6433
1531-4332
DOI:10.1016/S1095-6433(01)00537-2