Executive function deficits associated with symptoms of schizotypy and obsessive–compulsive disorder

Research suggests that executive dysfunction is seen both in disorders of the schizophrenia constellation and in obsessive–compulsive disorder (OCD), but that the patterns of executive deficits may differ. While disorders of the schizophrenia spectrum reflect impairment of functions such as integrat...

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Bibliographic Details
Published in:Psychiatry research 2002-06, Vol.110 (2), p.151-163
Main Authors: Spitznagel, Mary Beth, Suhr, Julie A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Anxiety Disorders - etiology
Anxiety disorders. Neuroses
Biological and medical sciences
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Dorsolateral prefrontal cortex
Female
Humans
Male
Medical sciences
Neuropsychological Tests
Obsessive-Compulsive Disorder - complications
Obsessive-compulsive disorders
Orbitofrontal cortex
Personality disorders
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Schizotypal Personality Disorder - complications
Severity of Illness Index
Spectrum research
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Summary:Research suggests that executive dysfunction is seen both in disorders of the schizophrenia constellation and in obsessive–compulsive disorder (OCD), but that the patterns of executive deficits may differ. While disorders of the schizophrenia spectrum reflect impairment of functions such as integration of cognitive activities, a tendency to perseverate, and a failure to notice details (e.g. impairment associated with the dorsolateral prefrontal cortex), OCD may involve problems of impulse control and regulation of behavior, and an inability to maintain cognitive set (e.g. impairment associated with the orbitofrontal cortex). The present study examined differences between high-scorers on a measure of schizotypy, high-scorers on a measure of OCD, high-scorers on both schizotypy and OCD and a control group in performance on executive function tests. As expected, the OCD group demonstrated relative deficits on measures thought to reflect orbitofrontal functioning. However, contrary to expectations, the schizotypal group did not demonstrate deficits on neuropsychological tests thought to reflect dorsolateral prefrontal cortex functioning, and the combined group showed no executive impairment.
ISSN:0165-1781
1872-7123
DOI:10.1016/S0165-1781(02)00099-9