Short-term consumption of a high-sucrose diet has a pro-oxidant effect in rats

The underlying mechanisms for the detrimental consequences of a high-fructose diet in animal models are not clear. However, the possibility exists that fructose feeding facilitates oxidative damage. Thus, the aim of the present study was to assess, in weaning rats, the effect of a high-sucrose diet...

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Bibliographic Details
Published in:British journal of nutrition 2002-04, Vol.87 (4), p.337-342
Main Authors: Busserolles, Jérôme, Rock, Edmond, Gueux, Elyett, Mazur, Andrzej, Grolier, Pascal, Rayssiguier, Yves
Format: Article
Language:English
Subjects:
Animal models
Animals
Antioxidants
Biological and medical sciences
Biomarkers - analysis
Diet
Dietary Sucrose - administration & dosage
Feeding. Feeding behavior
Free radicals
Fundamental and applied biological sciences. Psychology
Glutathione Peroxidase - analysis
High-sucrose diet
Liver - chemistry
Male
Myocardium - chemistry
Oxidative Stress
Oxidizing agents
Pancreas - chemistry
Peroxidation
Rats
Rats, Wistar
Starch
Starch - administration & dosage
Superoxide Dismutase - analysis
Thiobarbituric Acid Reactive Substances - analysis
Thymus Gland - chemistry
Time Factors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin E - analysis
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Summary:The underlying mechanisms for the detrimental consequences of a high-fructose diet in animal models are not clear. However, the possibility exists that fructose feeding facilitates oxidative damage. Thus, the aim of the present study was to assess, in weaning rats, the effect of a high-sucrose diet v. starch diet for 2 weeks on oxidative stress variables. Plasma lipid levels were measured and lipid peroxidation was evaluated by urine and plasma thiobarbituric acid-reactive substances (TBARS). The susceptibilities of several tissues to peroxidation were determined in tissue homogenates after in vitro lipid peroxidation. Antioxidant defence variables were evaluated by measuring plasma and heart vitamin E levels, and heart superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities. Higher plasma triacylglycerol (P
ISSN:0007-1145
1475-2662
DOI:10.1079/BJN2002524