Resolution of ternary mixtures of nitrofurantoin, furaltadone and furazolidone by partial least-square analysis to the spectrophotometric signals after photo-decomposition

An UV spectroscopic method is proposed to analyze mixtures of the nitrofuran derivatives, nitrofurantoin, furaltadone and furazolidone, used in veterinary. The change of absorption spectra due to photo-decomposition is used. A 20% dimethylformamide/water, basic medium of pH 9.4 (ammonium chloride/am...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2002-07, Vol.29 (3), p.477-485
Main Authors: Mahedero, M.C, Dı́az, T.Galeano, Pascual, S.Galán
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Furazolidone - analysis
General pharmacology
Hydrogen-Ion Concentration
Least-Squares Analysis
Medical sciences
Nitrofurans
Nitrofurans - analysis
Nitrofurantoin - analysis
Oxazolidinones - analysis
Partial least-square multivariate analysis method
Pharmacology. Drug treatments
Photo-decomposition
Spectrophotometry, Ultraviolet
UV absorption spectroscopy
Veterinary Drugs - analysis
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Summary:An UV spectroscopic method is proposed to analyze mixtures of the nitrofuran derivatives, nitrofurantoin, furaltadone and furazolidone, used in veterinary. The change of absorption spectra due to photo-decomposition is used. A 20% dimethylformamide/water, basic medium of pH 9.4 (ammonium chloride/ammonia) and a time of irradiation of 15 s are selected. Calibration graphs are established, with the percentage of decrease of absorbance as analytical signal, in the range 2–10 μg ml −1. To analyze mixtures of the three compounds the partial least-squares (PLS) multivariate analysis method is used with the spectra obtained by subtracting the spectra after irradiation to the original spectra. Good results have been obtained in the analysis of synthetic samples and a formulation containing all these compounds.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(02)00092-4