Radamycin, a Novel Thiopeptide Produced by Streptomyces sp. RSP9: I. Taxonomy, Fermentation, Isolation and Biological Activities

The newly isolated strain Streptomyces sp. RSP9 produces two thiopeptides; one of them is methylsulfomycin I, which shows potent antibiotic activity against several Gram-positive bacteria such as Micrococcus luteus and Staphylococcus aureus. The other is a new thiopeptide named radamycin. In the pre...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 2002/04/25, Vol.55(4), pp.383-390
Main Authors: HOLGADO, GLORIA GONZÁLEZ, RODRÍGUEZ, JULIÁN CASTRO, HERNÁNDEZ, LIBRADA M. CAÑEDO, DÍAZ, MARGARITA, FERNÁNDEZ-ABALOS, JOSÉ MANUEL, TRUJILLANO, IGNACIO, SANTAMARÍA, RAMÓN I.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Applied microbiology
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Biological and medical sciences
Culture Media
Fermentation
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Bacterial
Gram-Positive Cocci - drug effects
Humans
Medical sciences
Microbial Sensitivity Tests
Microbiology
Peptides, Cyclic - biosynthesis
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Pharmacology. Drug treatments
Promoter Regions, Genetic
Streptomyces - classification
Streptomyces - growth & development
Streptomyces - isolation & purification
Streptomyces - metabolism
Trans-Activators
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The newly isolated strain Streptomyces sp. RSP9 produces two thiopeptides; one of them is methylsulfomycin I, which shows potent antibiotic activity against several Gram-positive bacteria such as Micrococcus luteus and Staphylococcus aureus. The other is a new thiopeptide named radamycin. In the present work, this compound was purified and tested against several microorganisms and no antibiotic activity was detected in the assays. However, it does have a very strong capacity as an inducer of the tipA promoter, and indeed is the first reported molecule with tipA promoter induction capacity without detectable antibiotic activity. Induction of the tipA promoter also occurs with methylsulfomycin I.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.55.383