AmpliBASE MT™: a Mycobacterium tuberculosis diversity knowledgebase

AmpliBASE MT™ is an online databank of high-resolution DNA fingerprints representing fluorescent amplified fragment length polymorphism (FAFLP) profiles or amplitypes developed for the Mycobacterium tuberculosis complex strains from 48 different countries. AmpliBASE MT™ is based on a relational data...

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Bibliographic Details
Published in:Bioinformatics 2004-04, Vol.20 (6), p.989-992
Main Authors: Majeed, Ahmed A., Ahmed, Niyaz, Rao, K. Rajender, Ghousunnissa, S., Kauser, Farhana, Bose, Buddhaditta, Nagarajaram, H. A., Katoch, V. M., Cousins, Debby V., Sechi, Leonardo A., Gilman, Robert H., Hasnain, Seyed E.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Database Management Systems
Databases, Nucleic Acid
DNA Fingerprinting - methods
Fundamental and applied biological sciences. Psychology
Gene Expression Profiling - methods
General aspects
Genetic Variation - genetics
Information Storage and Retrieval - methods
Internet
Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects)
Mycobacterium tuberculosis - genetics
Phenotype
Software
User-Computer Interface
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Summary:AmpliBASE MT™ is an online databank of high-resolution DNA fingerprints representing fluorescent amplified fragment length polymorphism (FAFLP) profiles or amplitypes developed for the Mycobacterium tuberculosis complex strains from 48 different countries. AmpliBASE MT™ is based on a relational database management system that is hyperlinked to visualize genotyping results in the form of DNA fingerprint images for individual strains. A flexible search system based on systematic comparisons of fragment sizes in base pairs allows inter-laboratory comparison of FAFLP profiles. Besides this, the database also displays previously published data on IS6110 profiles, spoligotypes, MIRU-VNTRs and large sequence polymorphisms along with the FAFLP records that will give the overall comparisons. Being the first of its kind, AmpliBASE MT™ is expected to be a very helpful tool in strengthening the concept of ‘geographic genomics’ and will be very helpful to molecular epidemiologists and those interested in diagnostic development for tuberculosis. Availability: http://210.212.212.4/index.html
ISSN:1367-4803
1460-2059
1367-4811
DOI:10.1093/bioinformatics/bth051