Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction

Apolipoprotein (APOE) epsilon4 allele has been associated with cardiac dysfunction in Alzheimer's disease and beta-thalassemia. We investigated the association between APOE genotypes and left ventricular dysfunction in a population of community-dwelling elderly subjects. This study was performe...

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Bibliographic Details
Published in:The American heart journal 2004-04, Vol.147 (4), p.685-689
Main Authors: Bleumink, Gysèle S, van Duijn, Cornelia M, Kingma, J Herre, Witteman, Jacqueline C M, Hofman, Albert, Stricker, Bruno H Ch
Format: Article
Language:English
Subjects:
Age Factors
Aged
Alleles
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E - genetics
Case-Control Studies
Cohort Studies
Female
Genotype
Heart Diseases - genetics
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Risk Factors
Ventricular Dysfunction, Left - genetics
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Summary:Apolipoprotein (APOE) epsilon4 allele has been associated with cardiac dysfunction in Alzheimer's disease and beta-thalassemia. We investigated the association between APOE genotypes and left ventricular dysfunction in a population of community-dwelling elderly subjects. This study was performed in the Rotterdam Study, a population-based prospective cohort study among elderly subjects. For 2206 participants, a baseline echocardiogram and blood specimens for APOE typing were available. Cardiac dysfunction was considered present when fractional shortening was
ISSN:1097-6744