Expression of cyclooxygenase-1 and -2 and clinicopathologic features of colorectal cancer in northern Thailand

Two isoforms of cyclooxygenase, COX-1 and COX-2, have been identified and shown to be involved in tumorigenesis. Although, overexpression of COX-2 in human cancers has been repeatedly reported, no data have hitherto been available for Thai patients. To cast light on the role(s) of COX enzymes in the...

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Bibliographic Details
Published in:Asian Pacific journal of cancer prevention : APJCP 2004-01, Vol.5 (1), p.44-49
Main Authors: Sankhasard, Seksan, Lertprasertsuk, Nirush, Vinitketkumnuen, Usanee, Cressey, Ratchada
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Blotting, Western
Case-Control Studies
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Cyclooxygenase 1
Cyclooxygenase 2
Female
Gene Expression Regulation, Neoplastic
Humans
Isoenzymes - biosynthesis
Male
Membrane Proteins
Middle Aged
Prostaglandin-Endoperoxide Synthases - biosynthesis
Thailand
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Summary:Two isoforms of cyclooxygenase, COX-1 and COX-2, have been identified and shown to be involved in tumorigenesis. Although, overexpression of COX-2 in human cancers has been repeatedly reported, no data have hitherto been available for Thai patients. To cast light on the role(s) of COX enzymes in the development and progression of colorectal cancers and to determine the incidence of COX-2 overexpression, the expression levels of COX-1 and COX-2 proteins using Western blot analysis in tumor tissues and adjacent normal tissues obtained from 44 Thai patients with colorectal cancer. Compared with paired normal tissues, COX-2 was overexpressed in 13 of 44 colorectal tumor tissues (29.5%). Overall, COX-2 levels in colorectal tumor specimens were significantly correlated with histological differentiation, in particular in the tumors with poor differentiation (p
ISSN:1513-7368