Role of unlabelled somatostatin analogues in the prevention of complications after elective pancreatic and peripancreatic surgery: a critical review

• Published in: Digestive and liver disease 2004-02, Vol.36, p.S121-S127
• Main Authors: Falconi, M, Salvia, R, Mascetta, G, Mantovani, W, Sartori, N, Butturini, G, Bassi, C, Pederzoli, P
• Format: Article
• Language: English
• Subjects: Complications; Double-Blind Method; Elective Surgical Procedures; Humans; Pancreatic fistula; Pancreatic Neoplasms - surgery; Pancreatic surgery; Postoperative Complications - prevention & control; Prospective Studies; Randomized Controlled Trials as Topic; Somatostatin - analogs & derivatives; Somatostatin - therapeutic use; Somatostatin analogues
• ISSN: 1590-8658; 1878-3562
• DOI: 10.1016/j.dld.2003.11.023

Although studies on the use of the somatostatin analogues in the elective pancreatic surgery are mostly prospective, double blind and randomised, the results are contradictory and not univocally interpretable. Through the examination of all randomised perspective works published on this subject, a critical interpretation is attempted which may give relevant suggestions for further studies. A new clinical, randomised, double blind and multicentric prospective trial should take into proper consideration even the changes which have occurred in the care of the patients. Over the years a significant decrease of postoperative hospital stay and a deeper awareness of the medical expenses have been observed. Moreover, since the drug has a potential advantage on specific pancreatic complications, only these must be considered among the end points of the study and the population studied will be limited exclusively to patients who underwent resection of the pancreatic head or of the periampullar region because of neoplastic disease. Finally, the selection of the centres that enrol the patients must be considered, since the expertise of each operator or of the team, affects, as an independent variable, both morbidity and mortality.