A promoter polymorphism in the CD14 gene is associated with elevated levels of soluble CD14 but not with IgE or atopic diseases

Background:  A polymorphism in the promoter region of the CD14 gene, C‐159T, has been shown to be associated with increased levels of soluble CD14 (sCD14) and decreased serum immunoglobulin E (IgE) and the expression of a more severe atopic phenotype in previous studies. Methods:  To test if these a...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2004-05, Vol.59 (5), p.520-525
Main Authors: Kabesch, M., Hasemann, K., Schickinger, V., Tzotcheva, I., Bohnert, A., Carr, D., Baldini, M., Hackstein, H., Leupold, W., Weiland, S. K., Martinez, F. D., Mutius, E., Bein, G.
Format: Article
Language:English
Subjects:
Adult
Allergic diseases
asthma
atopy
Biological and medical sciences
CD14
Child
Child, Preschool
Cytosine
Female
Genotype
Germany - epidemiology
Humans
Hypersensitivity - epidemiology
Immunoglobulin E
Immunoglobulin E - blood
Immunopathology
Lipopolysaccharide Receptors - blood
Lipopolysaccharide Receptors - chemistry
Lipopolysaccharide Receptors - genetics
Male
Medical sciences
Phenotype
polymorphism
Polymorphism, Genetic
Prevalence
Promoter Regions, Genetic
single nucleotide polymorphism
Solubility
soluble CD14
Thymine
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Summary:Background:  A polymorphism in the promoter region of the CD14 gene, C‐159T, has been shown to be associated with increased levels of soluble CD14 (sCD14) and decreased serum immunoglobulin E (IgE) and the expression of a more severe atopic phenotype in previous studies. Methods:  To test if these associations are consistently found in different populations and different age groups, we genotyped 2048 children of different age groups as well as 888 adults from different regions of Germany for the CD14 C‐159T polymorphism. Results:  While an association between this promoter polymorphism and levels of sCD14 could be confirmed in our study population (CC: 1017 ng/ml vs TT: 1370 ng/ml, P = 0.03), no association between CD14 C‐159T genotypes and IgE levels or the prevalence of atopic diseases was seen. Conclusions:  The lack of association between CD14 genotypes and IgE as well as atopic outcomes in this large German study population seems to indicate that CD14 genotypes may not directly be involved in the development of allergies during childhood.
ISSN:0105-4538
1398-9995
DOI:10.1111/j.1398-9995.2004.00439.x