Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis

Summary Background It has been suggested that acute infantile bronchiolitis associated with respiratory syncytial virus (RSV) may share some pathogenic features with atopic asthma in that virus‐specific IgE is produced and cysteinyl leukotrienes (cLTs) and eosinophil cationic protein (ECP) have been...

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Bibliographic Details
Published in:Clinical and experimental allergy 2004-04, Vol.34 (4), p.555-558
Main Authors: Dimova-Yaneva, D., Russell, D., Main, M., Brooker, R. J., Helms, P. J.
Format: Article
Language:English
Subjects:
Allergic diseases
Biological and medical sciences
Blood Proteins - biosynthesis
bronchiolitis
Bronchiolitis, Viral - immunology
Chronic obstructive pulmonary disease, asthma
Cysteine - biosynthesis
ECP
Eosinophil Granule Proteins
eosinophils
Eosinophils - immunology
Female
Humans
Immunopathology
Infant
Infant, Newborn
infants
Leukotriene C4 - biosynthesis
Leukotrienes - biosynthesis
LTC4
Male
Medical sciences
Nasal Lavage Fluid - immunology
Pneumology
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - immunology
Respiratory Syncytial Virus, Human
Ribonucleases - biosynthesis
RSV
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Summary:Summary Background It has been suggested that acute infantile bronchiolitis associated with respiratory syncytial virus (RSV) may share some pathogenic features with atopic asthma in that virus‐specific IgE is produced and cysteinyl leukotrienes (cLTs) and eosinophil cationic protein (ECP) have been detected in airway secretions. ECP is a specific marker of eosinophil activation although leukotrienes can be released from a variety of cells including mast cells, eosinophils and monocytes. Objective To test the association between eosinophil activation and cysteinyl leukotriene production in the upper airway secretions of infants with RSV positive (RSV+ve) bronchiolitis. Methods Nasal lavage samples were performed in 78 infants (0.0–11.5 months) admitted to hospital with RSV+ve bronchiolitis soon after admission (0–48 h). Leukotriene C4 (LTC4) was assayed by enzyme immunoassay (EIA) and eosinophil cationic protein (ECP) by fluoroimmunoassay (FIA). Results LTC4 was detectable in 51 and ECP in 57 of 78 samples with a significant positive relationship between LTC4 and ECP (r=0.557, P
ISSN:0954-7894
1365-2222
DOI:10.1111/j.1365-2222.2004.1918.x