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Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis
Summary Background It has been suggested that acute infantile bronchiolitis associated with respiratory syncytial virus (RSV) may share some pathogenic features with atopic asthma in that virus‐specific IgE is produced and cysteinyl leukotrienes (cLTs) and eosinophil cationic protein (ECP) have been...
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| Published in: | Clinical and experimental allergy 2004-04, Vol.34 (4), p.555-558 |
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| cites | cdi_FETCH-LOGICAL-c4888-3c75b43bfafb23edf03c66d972cc38a559448091d67d83595a541d22dd7f953b3 |
| container_end_page | 558 |
| container_issue | 4 |
| container_start_page | 555 |
| container_title | Clinical and experimental allergy |
| container_volume | 34 |
| creator | Dimova-Yaneva, D. Russell, D. Main, M. Brooker, R. J. Helms, P. J. |
| description | Summary
Background
It has been suggested that acute infantile bronchiolitis associated with respiratory syncytial virus (RSV) may share some pathogenic features with atopic asthma in that virus‐specific IgE is produced and cysteinyl leukotrienes (cLTs) and eosinophil cationic protein (ECP) have been detected in airway secretions. ECP is a specific marker of eosinophil activation although leukotrienes can be released from a variety of cells including mast cells, eosinophils and monocytes.
Objective
To test the association between eosinophil activation and cysteinyl leukotriene production in the upper airway secretions of infants with RSV positive (RSV+ve) bronchiolitis.
Methods
Nasal lavage samples were performed in 78 infants (0.0–11.5 months) admitted to hospital with RSV+ve bronchiolitis soon after admission (0–48 h). Leukotriene C4 (LTC4) was assayed by enzyme immunoassay (EIA) and eosinophil cationic protein (ECP) by fluoroimmunoassay (FIA).
Results
LTC4 was detectable in 51 and ECP in 57 of 78 samples with a significant positive relationship between LTC4 and ECP (r=0.557, P |
| doi_str_mv | 10.1111/j.1365-2222.2004.1918.x |
| format | article |
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Background
It has been suggested that acute infantile bronchiolitis associated with respiratory syncytial virus (RSV) may share some pathogenic features with atopic asthma in that virus‐specific IgE is produced and cysteinyl leukotrienes (cLTs) and eosinophil cationic protein (ECP) have been detected in airway secretions. ECP is a specific marker of eosinophil activation although leukotrienes can be released from a variety of cells including mast cells, eosinophils and monocytes.
Objective
To test the association between eosinophil activation and cysteinyl leukotriene production in the upper airway secretions of infants with RSV positive (RSV+ve) bronchiolitis.
Methods
Nasal lavage samples were performed in 78 infants (0.0–11.5 months) admitted to hospital with RSV+ve bronchiolitis soon after admission (0–48 h). Leukotriene C4 (LTC4) was assayed by enzyme immunoassay (EIA) and eosinophil cationic protein (ECP) by fluoroimmunoassay (FIA).
Results
LTC4 was detectable in 51 and ECP in 57 of 78 samples with a significant positive relationship between LTC4 and ECP (r=0.557, P<0.001).
Conclusion
In the majority of our subjects with RSV+ve bronchiolitis ECP and LTC4 were detectable in upper airway secretions and were significantly associated with each other. In this clinical setting much of the detected LTC4 within upper airway secretions is likely to originate from the eosinophil, an observation that may have implications for clinical management and for delineation of the underlying mechanisms associated with this illness.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.2004.1918.x</identifier><identifier>PMID: 15080807</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Allergic diseases ; Biological and medical sciences ; Blood Proteins - biosynthesis ; bronchiolitis ; Bronchiolitis, Viral - immunology ; Chronic obstructive pulmonary disease, asthma ; Cysteine - biosynthesis ; ECP ; Eosinophil Granule Proteins ; eosinophils ; Eosinophils - immunology ; Female ; Humans ; Immunopathology ; Infant ; Infant, Newborn ; infants ; Leukotriene C4 - biosynthesis ; Leukotrienes - biosynthesis ; LTC4 ; Male ; Medical sciences ; Nasal Lavage Fluid - immunology ; Pneumology ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - immunology ; Respiratory Syncytial Virus, Human ; Ribonucleases - biosynthesis ; RSV</subject><ispartof>Clinical and experimental allergy, 2004-04, Vol.34 (4), p.555-558</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Apr 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4888-3c75b43bfafb23edf03c66d972cc38a559448091d67d83595a541d22dd7f953b3</citedby><cites>FETCH-LOGICAL-c4888-3c75b43bfafb23edf03c66d972cc38a559448091d67d83595a541d22dd7f953b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15608071$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15080807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dimova-Yaneva, D.</creatorcontrib><creatorcontrib>Russell, D.</creatorcontrib><creatorcontrib>Main, M.</creatorcontrib><creatorcontrib>Brooker, R. J.</creatorcontrib><creatorcontrib>Helms, P. J.</creatorcontrib><title>Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Summary
Background
It has been suggested that acute infantile bronchiolitis associated with respiratory syncytial virus (RSV) may share some pathogenic features with atopic asthma in that virus‐specific IgE is produced and cysteinyl leukotrienes (cLTs) and eosinophil cationic protein (ECP) have been detected in airway secretions. ECP is a specific marker of eosinophil activation although leukotrienes can be released from a variety of cells including mast cells, eosinophils and monocytes.
Objective
To test the association between eosinophil activation and cysteinyl leukotriene production in the upper airway secretions of infants with RSV positive (RSV+ve) bronchiolitis.
Methods
Nasal lavage samples were performed in 78 infants (0.0–11.5 months) admitted to hospital with RSV+ve bronchiolitis soon after admission (0–48 h). Leukotriene C4 (LTC4) was assayed by enzyme immunoassay (EIA) and eosinophil cationic protein (ECP) by fluoroimmunoassay (FIA).
Results
LTC4 was detectable in 51 and ECP in 57 of 78 samples with a significant positive relationship between LTC4 and ECP (r=0.557, P<0.001).
Conclusion
In the majority of our subjects with RSV+ve bronchiolitis ECP and LTC4 were detectable in upper airway secretions and were significantly associated with each other. In this clinical setting much of the detected LTC4 within upper airway secretions is likely to originate from the eosinophil, an observation that may have implications for clinical management and for delineation of the underlying mechanisms associated with this illness.</description><subject>Allergic diseases</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - biosynthesis</subject><subject>bronchiolitis</subject><subject>Bronchiolitis, Viral - immunology</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Cysteine - biosynthesis</subject><subject>ECP</subject><subject>Eosinophil Granule Proteins</subject><subject>eosinophils</subject><subject>Eosinophils - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>infants</subject><subject>Leukotriene C4 - biosynthesis</subject><subject>Leukotrienes - biosynthesis</subject><subject>LTC4</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nasal Lavage Fluid - immunology</subject><subject>Pneumology</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections - immunology</subject><subject>Respiratory Syncytial Virus, Human</subject><subject>Ribonucleases - biosynthesis</subject><subject>RSV</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqNktFuFCEUhidGY7fVV1BionczwjAMkHjTrNtqUuuFNXpHGGCybGdhBabdeXsZd1ONN3ogOYR8_4HDT1G8RLBCOd5uKoRbUtY5qhrCpkIcsWr_qFg87D8uFpCTpqSMNyfFaYwbCCEmnD0tThCBLA-6KNLKR-v8bm0HIFWydzJZ74B0GqgpJmPdNIDBjLc-BWucAbvg9ah-QXaevXQpgnub1iCYuLNBJh8mECenpmTlAO5sGCPogndqbf1gk43Piie9HKJ5fsxnxdeL1c3yQ3n1-fLj8vyqVA1jrMSKkq7BXS_7rsZG9xCrttWc1kphJgnhTcMgR7qlmuXOiCQN0nWtNe05wR0-K94c6uZL_xhNTGJrozLDIJ3xYxQUMcQopv8EEeWUUthm8NVf4MaPweUmBOKc1y2sSYboAVLBxxhML3bBbmWYBIJitk9sxGyTmG0Ss31itk_ss_LFsfzYbY3-rTv6lYHXR0BGJYc-SKds_INrZwxl7t2Bu7eDmf73fLFcnc-rLC8Pcpu_wP5BLsOtaPN7EfHt-lJ8am_w9Rf2XbzHPwExNcb0</recordid><startdate>200404</startdate><enddate>200404</enddate><creator>Dimova-Yaneva, D.</creator><creator>Russell, D.</creator><creator>Main, M.</creator><creator>Brooker, R. J.</creator><creator>Helms, P. J.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200404</creationdate><title>Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis</title><author>Dimova-Yaneva, D. ; Russell, D. ; Main, M. ; Brooker, R. J. ; Helms, P. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4888-3c75b43bfafb23edf03c66d972cc38a559448091d67d83595a541d22dd7f953b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Allergic diseases</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - biosynthesis</topic><topic>bronchiolitis</topic><topic>Bronchiolitis, Viral - immunology</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Cysteine - biosynthesis</topic><topic>ECP</topic><topic>Eosinophil Granule Proteins</topic><topic>eosinophils</topic><topic>Eosinophils - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>infants</topic><topic>Leukotriene C4 - biosynthesis</topic><topic>Leukotrienes - biosynthesis</topic><topic>LTC4</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nasal Lavage Fluid - immunology</topic><topic>Pneumology</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory Syncytial Virus Infections - immunology</topic><topic>Respiratory Syncytial Virus, Human</topic><topic>Ribonucleases - biosynthesis</topic><topic>RSV</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dimova-Yaneva, D.</creatorcontrib><creatorcontrib>Russell, D.</creatorcontrib><creatorcontrib>Main, M.</creatorcontrib><creatorcontrib>Brooker, R. J.</creatorcontrib><creatorcontrib>Helms, P. J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dimova-Yaneva, D.</au><au>Russell, D.</au><au>Main, M.</au><au>Brooker, R. J.</au><au>Helms, P. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2004-04</date><risdate>2004</risdate><volume>34</volume><issue>4</issue><spage>555</spage><epage>558</epage><pages>555-558</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Summary
Background
It has been suggested that acute infantile bronchiolitis associated with respiratory syncytial virus (RSV) may share some pathogenic features with atopic asthma in that virus‐specific IgE is produced and cysteinyl leukotrienes (cLTs) and eosinophil cationic protein (ECP) have been detected in airway secretions. ECP is a specific marker of eosinophil activation although leukotrienes can be released from a variety of cells including mast cells, eosinophils and monocytes.
Objective
To test the association between eosinophil activation and cysteinyl leukotriene production in the upper airway secretions of infants with RSV positive (RSV+ve) bronchiolitis.
Methods
Nasal lavage samples were performed in 78 infants (0.0–11.5 months) admitted to hospital with RSV+ve bronchiolitis soon after admission (0–48 h). Leukotriene C4 (LTC4) was assayed by enzyme immunoassay (EIA) and eosinophil cationic protein (ECP) by fluoroimmunoassay (FIA).
Results
LTC4 was detectable in 51 and ECP in 57 of 78 samples with a significant positive relationship between LTC4 and ECP (r=0.557, P<0.001).
Conclusion
In the majority of our subjects with RSV+ve bronchiolitis ECP and LTC4 were detectable in upper airway secretions and were significantly associated with each other. In this clinical setting much of the detected LTC4 within upper airway secretions is likely to originate from the eosinophil, an observation that may have implications for clinical management and for delineation of the underlying mechanisms associated with this illness.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15080807</pmid><doi>10.1111/j.1365-2222.2004.1918.x</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0954-7894 |
| ispartof | Clinical and experimental allergy, 2004-04, Vol.34 (4), p.555-558 |
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| language | eng |
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| source | Wiley |
| subjects | Allergic diseases Biological and medical sciences Blood Proteins - biosynthesis bronchiolitis Bronchiolitis, Viral - immunology Chronic obstructive pulmonary disease, asthma Cysteine - biosynthesis ECP Eosinophil Granule Proteins eosinophils Eosinophils - immunology Female Humans Immunopathology Infant Infant, Newborn infants Leukotriene C4 - biosynthesis Leukotrienes - biosynthesis LTC4 Male Medical sciences Nasal Lavage Fluid - immunology Pneumology Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus, Human Ribonucleases - biosynthesis RSV |
| title | Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis |
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