Synthesis and evaluation of some new spiro indoline-based heterocycles as potentially active antimicrobial agents

Graphic Several new spiro indoline-based heterocycles were synthesized by prior preparation of the 4-(2 ′-oxo-indol-3 ′-ylidene)-oxazol-5-one derivatives and subsequent reaction of the produced indol-3-ylidene based heterocycles with activated nitrile reagents. The obtained products were allowed to...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2004-05, Vol.12 (9), p.2483-2488
Main Authors: Abdel-Rahman, A.H., Keshk, E.M., Hanna, M.A., El-Bady, Sh.M.
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial evaluations
Biological and medical sciences
Drug Evaluation, Preclinical
General aspects
Heterocyclic Compounds - chemical synthesis
Heterocyclic Compounds - pharmacology
Indoles - chemistry
Magnetic Resonance Spectroscopy
Medical sciences
Pharmacology. Drug treatments
Spectrophotometry, Infrared
Spiro indoline-based heterocycles
Synthesis
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Summary:Graphic Several new spiro indoline-based heterocycles were synthesized by prior preparation of the 4-(2 ′-oxo-indol-3 ′-ylidene)-oxazol-5-one derivatives and subsequent reaction of the produced indol-3-ylidene based heterocycles with activated nitrile reagents. The obtained products were allowed to react with hydrazine hydrate in alcoholic basic to give the target compounds. Structure of these products was confirmed on the bases of elemental as well as spectral data. Representative compounds of the hitherto synthesized products were tested and evaluated as antimicrobial agents.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2003.10.063