The effect of demineralized bone matrix gel on bone ingrowth and fixation of porous implants

• Published in: The Journal of arthroplasty 2002-06, Vol.17 (4), p.402-408
• Main Authors: Cook, Stephen D., Salkeld, Samantha L., Patron, Laura P., Barrack, Robert L.
• Format: Article
• Language: English
• Subjects: animal model; Animals; bone ingrowth; Bone Matrix; demineralized bone matrix (DBM); Dogs; Durapatite; Femur - surgery; hydroxyapatite (HA); implant fixation; Osseointegration; porous implants; Prostheses and Implants
• ISSN: 0883-5403; 1532-8406
• DOI: 10.1054/arth.2002.32169

The presence of demineralized bone matrix (DBM) gel did not enhance or accelerate attachment strength or bone ingrowth and resulted in a significant decrease in implant interface attachment strength at 3 weeks. Hydroxyapatite (HA) coating resulted in significant increases in interface shear strength and bone ingrowth compared with non–HA-coated porous implants at all time periods. The HA-coated implants achieved greater attachment strength and bone ingrowth at earlier time periods and maintained greater attachment strength at long-term periods. The results of this study indicate that in the presence of a good bone–implant interference fit, there is no beneficial effect in applying DBM gel to a porous-coated or HA-coated porous implant surface. The small amount that can be applied and the degree of osteoinductivity of DBM seem to preclude it from having a significant biologic effect. Copyright 2002, Elsevier Science (USA). All rights reserved.